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Updated: Jul 12, 2026

Analysis of the c-KIT Ligand Promoter Using Chromatin Immunoprecipitation
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IKKbetaサブユニットのリン酸化により,IkappaBキナーゼの活性を正または負の調節する

M Delhase1, M Hayakawa, Y Chen

  • 1Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0636, USA.

Science (New York, N.Y.)
|April 9, 1999
PubMed
まとめ

核因子カッパB (NF-kappaB) キナーゼβ (IKKbeta) の阻害剤は,IKKalphaと異なり,炎症信号によって活性化されます. この活性化はNF-kappaBのシグナル伝達につながるが,その後のIKKbetaの自己リン酸化は炎症反応を制限する.

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