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Updated: Jul 1, 2026

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NMDA受容体媒介によるK+流出とニューロンアポトシス

S P Yu1, C Yeh, U Strasser

  • 1Center for the Study of Nervous System Injury and Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Science (New York, N.Y.)
|April 9, 1999
PubMed
まとめ

N-メチル-D-アスパルテート (NMDA) 受容体を活性化すると,カリウム (K+) 流出が誘発され,神経細胞のアポトーシスが発生します. 細胞外K+の増加は,このK+の損失と細胞死亡を軽減し,脳イシュケミアの役割を示唆します.

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Overview
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Resting Membrane Potential

The relative difference in electrical charge, or voltage, between the inside and the outside of a cell membrane, is called the membrane potential. It is generated by differences in permeability of the membrane to various ions and the concentrations of these ions across the membrane.
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Resting Potential Decay01:15

Resting Potential Decay

The resting membrane potential of a neuron (-70mV) is sustained due to the selective ion permeability of the membrane. At the resting potential, the membrane is slightly permeable to ions like sodium (Na+) and chloride (Cl−) and highly permeable to potassium ions (K+). Differences in the ions' concentration inside the cell compared to the outside are maintained by membrane transport proteins like channels and pumps.
At rest, the K+ is the main ion that moves across the membrane through...