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血清のHDL-コレステロール濃度の決定因子としての血糖指数
1Department of Nutrition and Dietetics, Hammersmith Hospitals NHS Trust, London, UK. gfrost@rpms.ac.uk
Lancet (London, England)
|April 13, 1999
まとめ
ダイエット・グリケミック・インデックスは,HDLコレステロールレベルに大きな影響を与えます. 高血糖指数ダイエットは,HDLコレステロールの低下と関連しており,心臓の健康管理におけるその重要性を示唆しています.
科学分野:
- 栄養科学 栄養学 栄養科学は,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学は,栄養学が,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は
- 心血管の健康について
- メタボリック・ヘルス (代謝の健康)
背景:
- ダイエットは,冠動脈疾患 (CHD) の流行に大きく影響します.
- インスリン感受性とHDLコレステロールは,CHDの主要な代謝予測因子であり,どちらも食事によって影響されます.
- 高血糖指数炭水化物は食後のグルコースとインスリンを上昇させ,インスリン感受性を低下させ,心臓病のリスクを増やす.
研究 の 目的:
- 食事による血糖指数と血清のHDLコレステロール濃度との関係を調査する.
- 血糖指数がHDLコレステロールレベルの重要な決定要因であるかどうかを判断する.
主な方法:
- イギリスの成人の1986-87年の調査 (n=2200) の食事,人体測定,生化学データの再分析.
- 多重回帰モデルを使用して,血清脂質濃度 (総コレステロール,HDL,LDL) と食事要因との関連性を評価しました.
- 食事の変数として,血糖指数,炭水化物の種類,脂肪摂取量を調べました.
主要な成果:
- 血清のHDLコレステロールと食事による血糖指数との間に,男性と女性の両方で有意な負の関連が観察されました.
- この関係は統計的に有意であった (p=0.02 男性,p<0.0001 女性).
- 食事による血糖指数と総コレステロールまたはLDLコレステロール,または他の食事成分との間に有意な関連性は見つかりませんでした.
結論:
- ダイエット・グリセミック指数は,中年の成人における血清のHDLコレステロールと有意に関連した唯一の食事変数でした.
- ダイエットの血糖指数は,食事中の脂肪摂取量よりも血清のHDLコレステロールの有力な予測指標である.
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