新しい高血圧の発症の危険因子として,トレッドミルのテスト中の血圧応答. フレミングハムの心臓研究
J P Singh1, M G Larson, T A Manolio
1National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts 01702, USA.
Circulation
|April 13, 1999
まとめ
運動中の過度な静脈動脈血圧 (DBP) 反応は,男性と女性の両方で新発症の高血圧を予測します. 回復性シストリック血圧 (SBP) の上昇は,また,男性における高血圧リスクを示し,臨床前高血圧の変化を示唆しています.
科学分野:
- 心血管医学 心血管医学
- 高血圧の研究 高血圧の研究
- 運動生理学 運動生理学
背景:
- 運動による血圧反応と高血圧の予測に関する以前の研究は,少数の男性集団に限られていた.
- 運動と回復の血圧と将来の高血圧リスクの関連性は,男性と女性の大規模な集団ベースのサンプルで検証されなかった.
研究 の 目的:
- 運動と回復中のシストリック血圧 (SBP) とダイアストリック血圧 (DBP) と,新発症高血圧の発生率との関係を調査する.
- これらの関連性を,ノルモテンシブな中年男女の大規模な集団サンプルで評価する.
主な方法:
- ベースラインでノルモテンシブであったFramingham Offspring Studyの男性1026人と女性1284人のデータを活用した.
- ランニングミルの段階的な運動と回復の間に評価された血圧 (BP),誇張された応答と遅れた回復を定義します.
- 新規高血圧の発生率 (SBP ≥140 mm Hg,DBP ≥90 mm Hg,または抗高血圧薬の開始) を決定するために,8年間参加者を追跡しました.
主要な成果:
- 新規発症の高血圧は8年間で22%の男性と16%の女性で発症した.
- 運動中の過剰なDBP応答 (Ex-DBP 2) は,男性 (OR,4.16) と女性 (OR,2.17) の両方でインシデント高血圧を強く予測しました.
- 遅れたSBP回復 (R-SBP 3) は,特に運動期間とピーク運動BPを考慮すると,男性における高血圧を予測した (OR, 1.92).
結論:
- 運動中に過剰なダイアストリック血圧反応は,両性において将来の高血圧の有意な予測因子である.
- 運動から回復する際にシストリック血圧が上昇することは,男性における高血圧リスクの増加と関連しています.
- これらの運動による高血圧の変化は,高血圧の臨床前段階における亜臨床的病理生理学的変化を示す可能性があります.
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