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Updated: Aug 14, 2026

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

炎症促進媒介体は,窒素酸化物/循環性GMPに依存するメカニズムを通じて,動脈内の内皮由来ハイパーポラライジングファクターの形成を慢性的に下調調調節する

P Kessler1, R Popp, R Busse

  • 1Institut für Kardiovaskuläre Physiologie und Institut für Anaesthesiologie, Klinikum der J.W.G.-Universität, Frankfurt/Main, Germany.

Circulation
|April 13, 1999
PubMed
まとめ

炎症促進媒介剤は,酸化窒素合成酵素II (NOS II) を誘導することによって,動脈におけるエンドセリウム由来高極化因子 (EDHF) の形成を阻害する. このEDHFの減少は,動脈硬化症や敗血症などの疾患における内皮機能不全に寄与する.

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