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Updated: Jul 19, 2026

Reconstitution Of β-catenin Degradation In Xenopus Egg Extract
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ベータ-カタニンは,結腸がん細胞におけるサイクリンD1の発現を調節する

O Tetsu1, F McCormick

  • 1University of California, San Francisco, School of Medicine, Cancer Research Institute, 94143-0128, USA.

Nature
|April 14, 1999
PubMed
まとめ

アデノマ型ポリポシス・コリ (APC) 遺伝子の変異により,β-カタニンが蓄積され,大腸がんを誘発する. このβ-カテニンはサイクリンD1を活性化し,細胞サイクル進行と腫瘍の成長を促します.

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