集団における突然死を予測する:パリ展望研究I
1Service de Cardiologie, Hôpital Boucicaut, Paris, France. xavier.jouven@bcc.ap-hop-paris.fr
Circulation
|April 20, 1999
まとめ
親の突然死歴は,中年男性における突然死のリスクの独立した要因である. この発見は,早期予防戦略のリスクが高い個人を特定するのに役立ちます.
科学分野:
- 心臓病学 心臓病学
- 予防医学は,予防的な医療です.
- エピデミオロジー エピデミオロジー
背景:
- 突然の死は,冠動脈事件とリスク要因を共有し,特定の予測を困難にします.
- 両親の突然死歴は,リスク因子として以前調査されていませんでした.
研究 の 目的:
- 長期コホート研究において,突然の死に対する親の突然死を含むリスク要因を評価する.
主な方法:
- パリ展望研究I (1967-1972) の7746人の男性 (43-52歳) の分析.
- 身体検査,心電図,検査,詳細な家族病歴のアンケートを通じて収集されたデータです.
- 既知の心不全性疾患を有する男性を除外し,平均23年間,生命状態が追跡された.
主要な成果:
- 突然死の原因となる独立リスク要因は,静止時の心拍数,血圧,喫煙,BMI,糖尿病,コレステロール,および両親の突然死歴です.
- 両親の突然死は,他の混同因子とは関係なく,突然死が1.80倍増加した相対リスク (95%CI,1.11-2.88) と関連していました.
結論:
- 親の突然死は,中年の男性における突然死に対する独立した危険因子である.
- 急性死亡の家族的リスク要因は,高リスクの個人の特定を改善し,早期予防を促進することができます.
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