治療を受けていない高血圧患者における左心室質量と内皮依存性血管拡張の関係
F Perticone1, R Maio, R Ceravolo
1Department of Medicina Sperimentale e Clinica "G. Salvatore" University of Catanzaro, Italy.perticone@unicz.it
Circulation
|April 20, 1999
まとめ
高血圧は血管や心臓を損傷する. 高血圧の患者では,左心室質量 (LVM) の増加は,内皮に依存する血管拡張の低下と関連しており,高血圧によるダブルダメージを示唆しています.
科学分野:
- 心臓病学 心臓病学
- 血管生物学 血管生物学
- 高血圧の研究 高血圧の研究
背景:
- 高血圧は左心房高縮 (LVH) と内皮機能不全と関連しています.
- 高血圧における心臓構造と血管機能の相互作用を評価することは極めて重要です.
研究 の 目的:
- 治療を受けていない高血圧患者におけるエコーカルディオグラフィック左心室質量 (LVM) と内皮依存性血管拡張の関係を調査する.
主な方法:
- エコカルディオグラフィは,65人の高血圧患者でLVMを測定するために使用されました.
- 内皮機能は,アセチルコリン (ACh) とナトリウムニトロプルーシド (SNP) の注射に対する前腕の血流 (FBF) 反応によって評価されました.
- LVMは,体表面積と身長で2.7乗までインデックスされていました.
主要な成果:
- AChに対するインデックスされたLVMとFBFの反応 (r=-0.554;P<0.0001) の間には,有意な逆相関が観察されました.
- LVHの患者は,LVHのない患者と比較して,ACHに対するFBF反応が有意に低かった (9.9+/-3.7 vs 16.1+/-8.1 mL/100 mL/min;P<0.0001).
- SNPに対するLVMとFBFの反応の間に有意な相関は見つかりませんでした.
結論:
- エコーカルディオグラフィのLVMは,高血圧患者の内皮依存性血管拡張と逆関係があります.
- 高血圧は,左心室と内皮の両方の損傷に寄与する可能性があります.
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