心拍数変動の遺伝性: フレミングハム心臓研究

J P Singh¹, M G Larson, C J O'Donnell

¹National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA.

Circulation

|May 5, 1999

まとめ

遺伝的要因は,心拍数 (HR) と心拍数変動 (HRV) に著しく影響する. この研究は,これらの自律神経系マーカーの遺伝性を定量化し,それらの実質的な遺伝的貢献を明らかにしています.

科学分野:

心血管生理学心血管の生理学
遺伝学遺伝学とは
自律神経系とは,自律神経系である.

背景:

心拍数 (HR) の遺伝的決定を示唆する証拠が増えています.
パワースペクトル分析による心拍数変動 (HRV) は,自律神経系 (ANS) 活動の定量的マーカーを提供します.
既存の決定因子は,HRとHRVの集団の変動を不完全に説明します.

研究の目的:

HRとHRVの遺伝性を評価する.
HRとHRVの変数に対する遺伝因子の寄与を推定する.

主な方法:

適格な被験者 (特定の病状や薬剤を服用している被験者を除く) の出張心電図記録の分析.
高周波,低周波,非常に低周波の電力,総電力,LF/HF比,SDNNを含むHRVパラメータの定量化.
兄弟姉妹と配偶者ペアの相関を用いた遺伝性分析,共変数で調整され,差異成分 (共変数,添加遺伝学,家庭効果) を推定する.

主要な成果:

HRとHRVの測定のための兄弟の相関は0.21から0.26の範囲で,配偶者相関 (0.01から0.19) よりも著しく高かった.
測定された共変数は,全現象型変数の13%から40%を説明した.
遺伝的要因は,HRとHRVの測定値の変動の13%から23%を占めています.

結論:

遺伝的要因は,HRとHRVで観察されたバリエンスに大きく寄与しています.
これらの発見は,ANS活動に対する遺伝子と環境の影響の相互作用を強調しています.

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