高血圧性心疾患におけるダイアストリック機能不全は,心筋の代謝の変化と関連しています
H J Lamb1, H P Beyerbacht, A van der Laarse
1Department of Radiology and Cardiology, University Medical Center, Leiden The Netherlands. Lamb@RULLF2.Medfac.Leidenuniv.nl
Circulation
|May 5, 1999
まとめ
高血圧は,高血圧性心疾患の患者の心筋高エネルギーリン酸代謝を変化させる. この代謝の変化は,左心室のダイアストリック機能の障害と関連しており,心臓の健康における重要な関連性を強調しています.
科学分野:
- 心臓病学 心臓病学
- バイオケミストリー バイオケミストリー
- メディカルイマージング (医学イメージング)
背景:
- 高血圧は,しばしば左心房 (LV) の縮と機能不全につながる一般的な臨床問題です.
- 心筋高血圧性心疾患が心筋高エネルギーリン酸 (HEP) 代謝に与える影響と,LV機能不全との関連は不明である.
研究 の 目的:
- ヒトの高血圧性心疾患における心筋高血圧性HEP代謝の変化を調査する.
- 高血圧患者における心筋高血圧代謝の変化とLV機能不全との関係を決定する.
主な方法:
- 11人の高血圧患者と13人の健康な対照群で,磁気共鳴画像 (MRI) とリン-31磁気共鳴光譜 (31P-MRS) を利用した.
- 評価された LV 質量,ダイアストリック機能パラメータ (例えば,壁の希薄化のピーク率,E/A 比率),および静止状態およびストレスのときの心筋リンパクレアチン (PCr) /ATP 比率.
主要な成果:
- 高血圧の患者は,対照群と比較して,LVの質量増加とLVのダイアストリック機能の低下を示した.
- 心筋PCr/ATP比は,休息状態とストレス状態の両方で高血圧患者で有意に低下しました.
- PCr/ATP比は,静脈動脈機能と心臓の労働負荷の測定値と相関していた.
結論:
- 心筋高血圧性心疾患の患者では,心筋高血圧性HEPの代謝が変化する.
- 高血圧患者におけるLVダイアストリック機能の障害は,心筋HEP代謝の変化と関連しています.
- 心筋のPCr/ATPレベルは,心臓の労働負荷によって影響されるようです.
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