関連する実験動画
Updated: Jul 12, 2026
08:13
Optical Mapping of Action Potentials and Calcium Transients in the Mouse Heart
Published on: September 13, 2011
心房細動中の心房節伝導:心房の入力変化の役割
S Garrigue1, K A Mowrey, G Fahy
1Department of Cardiology, the Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Circulation
|May 5, 1999
まとめ
動脈動 (AF) に対するポステロセプトル切除は,AV結節の遅い経路を排除しません. 静脈回路の減速は,静脈回路ノードル爆撃の減少によるものであって,経路の減速によるものではない.
科学分野:
- 心臓病学 心臓病学
- 電気生理学 電気生理学
- 心臓外科手術について
背景:
- ポステロセプタル切除は,心房細動 (AF) 中の心房速度を制御するために心房細動節 (AVN) を標的とする.
- 推定されるメカニズムは,AVNの遅い経路を排除することです.
- 予測不能な成功率は,代替メカニズムが作用していることを示唆している.
研究 の 目的:
- シミュレートされた心房動の間に,AVNの遅い経路に対するポステロセプトル除去の効果を調査する.
- 心室速度の減速が,経路の緩慢な除去によるものなのか,または AV節点爆撃の減少によるものなのかを判断する.
主な方法:
- ウサギの心臓のアトリアル-AVN製剤を使用した.
- 経路効果を評価するために,AVNへの冷却を適用したアプローチ.
- ポステロセプタル手術前後のAFをシミュレートし,His-His (H-H) 間隔とAVノードル爆撃率をモニタリングします.
主要な成果:
- 後冷却はAVN経路に非特異的な効果を示した.
- AF中のポステロセプタル切断は,H-H間隔を延長し,最小のH-Hに影響を与えることなくAVノードル爆撃を遅らせ,無傷の遅い経路を示しています.
- 前のAFの起源と切断は,H-H間隔や爆撃速度を変えない.
結論:
- ポステロスペタル切除は,AVNの遅い経路を排除しません.
- ポステロセプトル除去後のAFでは,潜在的に前後心房内閉塞を介して,AVノードル爆撃を減少させることで,心房内閉塞のペースの減速が達成されます.
関連する概念動画
01:13The Cardiac Cycle
The heart beats rhythmically in a sequence called the cardiac cycle—a rapid coordination of contraction (systole) and relaxation (diastole).
The Process
Electrical signals—sent from the sinoatrial (SA) node in the right atrial wall to the atrioventricular (AV) node between the right atrium and right ventricle—cause both atria to simultaneously contract. When the signal reaches the AV node, it pauses for approximately a tenth of a second, allowing the atria to contract and empty blood into the...
The Process
Electrical signals—sent from the sinoatrial (SA) node in the right atrial wall to the atrioventricular (AV) node between the right atrium and right ventricle—cause both atria to simultaneously contract. When the signal reaches the AV node, it pauses for approximately a tenth of a second, allowing the atria to contract and empty blood into the...
01:16Heart Valves
The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
01:29Cardiac Cycle
The cardiac cycle refers to the sequence of events that occur in the heart from the beginning of one heartbeat to the next. It's characterized by alternating periods of contraction (systole) and relaxation (diastole) of the heart muscles.
During the cardiac cycle, blood flow through the heart is regulated entirely by changing pressure gradients. This sequence of events begins with the heart in a state of total relaxation, known as mid-to-late diastole, during which blood passively flows from...
During the cardiac cycle, blood flow through the heart is regulated entirely by changing pressure gradients. This sequence of events begins with the heart in a state of total relaxation, known as mid-to-late diastole, during which blood passively flows from...
01:31Regulation of Heart Rates
The regulation of heart rate is a complex process controlled by the autonomic nervous system (ANS), hormonal influences, and intrinsic cardiac mechanisms. The ANS has two main components: the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS).
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...
01:18Physiology of the Heart: The Cardiac Cycle
The cardiac cycle describes the events from one heartbeat to the next. It includes three main phases: diastole, atrial systole, and ventricular systole, all driven by changes in chamber pressures and the function of heart valves.
Diastole: The Relaxation Phase
During diastole, all four heart chambers relax. The atrioventricular (AV) valves open, and the semilunar valves close. This phase sees the lowest chamber pressures, promoting ventricular filling. Venous blood enters the heart through the...
Diastole: The Relaxation Phase
During diastole, all four heart chambers relax. The atrioventricular (AV) valves open, and the semilunar valves close. This phase sees the lowest chamber pressures, promoting ventricular filling. Venous blood enters the heart through the...
01:20Conduction System of the Heart
The cardiac conduction system produces and transmits electrical impulses that prompt myocardial contraction, ensuring efficient heart function. This intricate system ensures that the heart beats in a coordinated and efficient manner, beginning with the atria and then the ventricles. The conduction system optimizes cardiac output by maintaining this precise sequence, which is crucial for adequate blood circulation.
This system relies on the unique properties of nodal and Purkinje cells:...
This system relies on the unique properties of nodal and Purkinje cells:...