ホルモン補充療法と乳がんの高S相は,
M A Cobleigh1, F E Norlock, D M Oleske
1Section of Medical Oncology, Rush-Presbyterian-St Luke's Medical Center, Chicago, Ill 60612, USA.
JAMA
|May 5, 1999
まとめ
閉経後のホルモン置換療法 (HRT) の使用は,エストロゲン受容体陽性乳がんの成長を刺激するように見え,これはより高いS相分数によって示されます. ER陰性腫瘍と予後に対する影響は不明である.
科学分野:
- 腫瘍学 腫瘍学
- エンドクリノロジー エンドクリノロジー
- がん生物学 がん生物学
背景:
- 長期にわたる閉経後のホルモン置換療法 (HRT) は,乳がんの発生率の増加と死亡率の低下に関連しています.
- この不一致の生物学的な根拠は,調査が必要である.
研究 の 目的:
- HRT使用者における乳がんの予後特性を,HRT使用者とは比較するために.
- 腫瘍細胞増殖に対するHRTの影響を調査する.
主な方法:
- プロスペクティブコホート研究 (1989年-1996年) は,349種類の浸食性乳がんを患った331人の閉経後の女性を対象としたものです.
- エストロゲン受容体 (ER) ステータスとS相分子の分析,現在のHRT使用者に対して,これまで使用したことがない者に対して.
主要な成果:
- HRT使用者は,高S相分数の頻度が著しく高かったことを示した (OR, 2.82).
- この増加は主にER陽性がん (OR,5.25) で観察され,ER陰性がん (OR,1.08) で観察されなかった.
結論:
- HRTの使用は,S相分数によって示されるように,ER陽性乳がんの成長を刺激する可能性があります.
- ER陽性腫瘍を有するHRT使用者に対する予後的な影響は,現在不明です.
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