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Updated: Jul 5, 2026

Determining Optimal Cytotoxic Activity of Human Her2neu Specific CD8 T cells by Comparing the Cr51 Release Assay to the xCELLigence System
11:31

Determining Optimal Cytotoxic Activity of Human Her2neu Specific CD8 T cells by Comparing the Cr51 Release Assay to the xCELLigence System

Published on: August 8, 2012

誤って選択されたCD8T細胞がCD8遺伝子メチル化によって無活性化され,細胞が死亡する

G A Pestano1, Y Zhou, L A Trimble

  • 1Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston MA 02115, USA.

Science (New York, N.Y.)
|May 15, 1999
PubMed
まとめ

誤った選択されたCD8細胞は,ポスチム性品質管理メカニズムによって浄化されます. T細胞受容体 (TCRs) とCD8コアレセプター (CD8 coreceptors) の活性化に失敗すると,アポトーシス (apoptosis) が引き起こされ,自己免疫疾患が予防されます.

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