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鬱病の青年は,大人になってから
M M Weissman1, S Wolk, R B Goldstein
1Division of Clinical and Genetic Epidemiology, College of Physicians and Surgeons, Columbia University, New York State Psychiatric Institute, New York 10032, USA. weissman@child.cpmc.columbia.edu
JAMA
|May 18, 1999
まとめ
大うつ病 (MDD) は青春期の自殺リスクを大幅に高め,成人期まで持続し,より高いうつ病率,入院,機能障害につながる. 早期発見と治療は,青春期のMDD患者にとって極めて重要です.
科学分野:
- 精神科医は精神病を患っている.
- 発達心理学の心理学について
- 臨床流行病学 臨床流行病学とは
背景:
- 青春期の重度うつ病 (MDD) は,機能障害と自殺リスクに関連しています.
- 青春期発症のMDDの成人期への長期的な臨床経過に関するデータは限られている.
研究 の 目的:
- 大型うつ病 (MDD) の継続性を,青春期から成人期まで調査する.
- 青春期発症のMDDの臨床結果と長期的な影響を記述する.
主な方法:
- 予見的なケース・コントロール研究では,青春期発症のMDDと37人の健康な対照群の73人の被験者を追跡した.
- 初期評価は1977年から1985年 (タナー・ステージIII-V) 間に実施され,フォローアップは10年から15年 (1992年から1996年) 後に実施された.
- 評価されたアウトカムには,自殺,精神病診断,治療,社会的機能が含まれていました.
主要な成果:
- 青春期発症のMDDは,7.7%の自殺率と,自殺未遂の5倍のリスクに関連していました.
- 思春期のMDDを患った個人は,成人期に再発するMDDのリスクが2倍に増加したが,他の精神疾患はそうではなかった.
- 社会的,労働的,および家族の機能の障害が一般的であり,成人期にエピソードフリーになるのはわずか37%で,対照群の69%と比較した.
結論:
- 青春期発症のMDDは,成人期にわたって有意な継続性,特異性,罹病率,死亡リスクを示しています.
- 思春期のMDDの早期発見とエビデンスに基づく治療は強く推奨されています.
- 発見は,うつ病と診断された青少年に対する継続的なメンタルヘルスサポートの必要性を強調しています.
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