タイプIIIの分泌装置:宿主細胞にタンパク質を供給するバクテリアの装置

J E Galán¹, A Collmer

¹Section of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale School of Medicine, New Haven, CT 06536, USA. jorge.galan@yale.edu

Science (New York, N.Y.)

|May 21, 1999

まとめ

グラム陰性細菌は,III型分泌システムを用いて,宿主細胞にエフェクタータンパク質を注入し,細胞機能に影響を及ぼします. これらのシステムを研究することで,感染症に対する新たな治療戦略が生まれます.

科学分野:

微生物学微生物学とは
分子生物学は分子生物学である.
パトジェネシス (病原生)

背景:

グラム陰性病原性細菌は,特殊なタンパク質分泌システムを利用しています.
型III分泌システム (T3SS) は,細菌の毒性にとって極めて重要です.
T3SSは進化的にバクテリアのフラゲラと関連しています.

研究の目的:

タイプIIIの分泌システムの機能と重要性を明らかにする.
T3SS.によって提供されるエフェクタータンパク質の多様性を理解する.
T3SS.をターゲットにした潜在的な治療的応用を探求する.

主な方法:

異なる細菌種におけるT3SSの比較分析.
T3SSと鞭状器官の間の進化的関係を調査する.
エフェクタータンパク質と宿主細胞の調節機能を特徴づける.

主要な成果:

T3SSは,植物や動物に影響を与える多様な細菌病原体で保存されています.
T3SSによって提供されるエフェクタータンパク質は,種特有である.
T3SSは宿主細胞の機能を調節する上で重要な役割を果たします.

結論:

T3SSの生物学を理解することは,新しい抗感染戦略の開発の鍵です.
T3SSをターゲットにすることは,細菌感染症の予防と治療のための有望な道を提供します.
T3SSの保存された性質は,変化する効果因子にもかかわらず,保存された毒性のメカニズムを強調しています.

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