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関連する概念動画

Phagocytosis00:41

Phagocytosis

Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis (“cellular eating”) is one of three major types of endocytosis. Cells use phagocytosis to take in large objects—such as other cells (or their debris), bacteria, and even viruses.The objective of phagocytosis is often destruction. Cells use phagocytosis to eliminate unwelcome visitors, like pathogens (e.g., viruses and bacteria). It is perhaps unsurprising, that many...
What is Monogastric Digestion?01:50

What is Monogastric Digestion?

The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
The Angiosperm Life Cycle02:39

The Angiosperm Life Cycle

Plants have a life cycle split between two multicellular stages: a haploid stage—with cells containing one set of chromosomes—and a diploid stage—with cells containing two sets of chromosomes. The haploid stage is the gamete-producing gametophyte, and the diploid stage is the spore-producing sporophyte.
Phagocytosis00:41

Phagocytosis

Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis ("cellular eating") is one of three major types of endocytosis. Cells use phagocytosis to take in large objects, such as other cells (or their debris), bacteria, and even viruses.
The objective of phagocytosis is often destruction. Cells use phagocytosis to eliminate unwelcome visitors, like pathogens (e.g., viruses and bacteria). Many immune system cells, including...
Digestive Functions of the Large Intestine01:20

Digestive Functions of the Large Intestine

The large intestine is where the final stages of digestion happen. When the cecum receives chyme, it contains undigested carbohydrates that undergo fermentation. Gut bacteria ferment these carbohydrates to produce short-chain fatty acids that provide some energy and help synthesize essential vitamins.
As the chyme moves to the colon, it triggers two characteristic sluggish contractions - haustral churning and mass peristalsis. Haustral churning involves the rhythmic contraction and relaxation...
The Mammary Glands01:12

The Mammary Glands

The female breast is a hemispheric projection of variable size positioned anterior to the pectoralis major and serratus anterior muscles. A fascia layer composed of dense, irregular connective tissue connects it to these muscles.
Each breast features a pigmented projection known as the nipple, through which milk emerges via closely spaced openings of ducts, referred to as lactiferous ducts. Surrounding the nipple is a circular pigmented area of skin named the areola, which appears rough due to...

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関連する実験動画

Updated: Jun 30, 2026

Indirect Immunofluorescence on Frozen Sections of Mouse Mammary Gland
11:13

Indirect Immunofluorescence on Frozen Sections of Mouse Mammary Gland

Published on: December 1, 2015

哺乳類のテロメアは,大きな二重ループで終わる.

J D Griffith1, L Comeau, S Rosenfield

  • 1Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill and Curriculum in Genetics and Molecular Biology, 27599-7295, USA. jdg@med.unc.edu

Cell
|May 25, 1999
PubMed
まとめ

テロメア保護タンパク質TRF2は,テロメアDNAを大きな二重ループ (tループ) に再構成する. 人間とマウスの細胞で見られるこれらのtループは,染色体の末端を保護し複製する可能性があります.

科学分野:

  • 細胞生物学 細胞生物学
  • 分子生物学は分子生物学である.
  • 遺伝学 遺伝学とは

背景:

  • 哺乳類のテロメアは,TRF1およびTRF2.2を含むタンパク質に結合した繰り返しDNA配列で構成されています.
  • TRF2はテロメア末端の保護に不可欠であり,その抑制は染色体末端の脱保護と融合につながる.

研究 の 目的:

  • テロメア維持におけるTRF2の構造的役割を調査する.
  • テロメア末端保護のメカニズムを解明する.

主な方法:

  • 電子顕微鏡を用いたインビトロ生化学測定法で,DNAの構造変化を観察する.
  • 電子顕微鏡を用いたヒトとマウスの細胞からのプソラレンのクロスリンクテロメリックDNAの分析.

主要な成果:

  • TRF2は線形テロメアDNAを in vitro で大きな二重ループ (tループ) に再構成することが示されました.
  • 人とマウスの細胞からのテロメアDNAに豊富なtループが特定されました.
  • 証拠によると,tループは,TRF1および単一鎖結合タンパク質を含む二重テロメア配列への3'オーバーハン侵入によって形成される.

結論:

さらに関連する動画

Transfer of Mammary Gland-forming Ability Between Mammary Basal Epithelial Cells and Mammary Luminal Cells via Extracellular Vesicles/Exosomes
09:59

Transfer of Mammary Gland-forming Ability Between Mammary Basal Epithelial Cells and Mammary Luminal Cells via Extracellular Vesicles/Exosomes

Published on: June 3, 2017

Bovine Mammary Gland Biopsy Techniques
14:53

Bovine Mammary Gland Biopsy Techniques

Published on: December 23, 2018

関連する実験動画

Last Updated: Jun 30, 2026

Indirect Immunofluorescence on Frozen Sections of Mouse Mammary Gland
11:13

Indirect Immunofluorescence on Frozen Sections of Mouse Mammary Gland

Published on: December 1, 2015

Transfer of Mammary Gland-forming Ability Between Mammary Basal Epithelial Cells and Mammary Luminal Cells via Extracellular Vesicles/Exosomes
09:59

Transfer of Mammary Gland-forming Ability Between Mammary Basal Epithelial Cells and Mammary Luminal Cells via Extracellular Vesicles/Exosomes

Published on: June 3, 2017

Bovine Mammary Gland Biopsy Techniques
14:53

Bovine Mammary Gland Biopsy Techniques

Published on: December 23, 2018

  • テロメア再結合因子2 (TRF2) は,テロメアループ (tループ) の形成に重要な役割を果たします.
  • Tループは哺乳類の細胞に保存された構造であり,テロメアの保護と複製のためのメカニズムとして機能する可能性があります.