ホメオボックス遺伝子"Phox2b"は,自律神経頂部派生体の発達に不可欠である
1Laboratoire de Génétique et Physiologie du Développement, Developmental Biology Institute of Marseille, CNRS/INSERM/Université de la Méditterranée/AP de Marseille, France.
Nature
|June 9, 1999
まとめ
ホメオドメインの転写因子Phox2bは,自律性ガンジアの発達に不可欠である. その欠如は,交感性,寄交感性,腸性ニューロンの形成と生存を妨げます.
科学分野:
- 神経科学は神経科学である.
- 発達生物学 発達生物学について
- 遺伝学 遺伝学とは
背景:
- 周辺的自律神経系には,交感性,寄交感性,腸性ガングリアがあり,これらはすべて神経の頂上細胞から発生します.
- 自律性ギャングリアの発達における重要な要因には,転写因子Mash1,膠質由来神経栄養因子 (GDNF) およびその受容体,および神経ルギンの信号伝達が含まれます.
研究 の 目的:
- ホメオドメインの転写因子Phox2bが自律性ガンジュリアの発達と生存における役割を調査する.
- Phox2bが自律神経細胞の分化と現象型に影響を与える分子メカニズムを解明する.
主な方法:
- Phox2b欠乏したマウスの分析により,自律性ガンジリアの形成と生存を観察した.
- 遺伝子発現分析 重要な発達因子 (Ret, Mash1) と神経伝達物質バイオシンセシス酵素 (ドーパミン-β-ヒドロキシラーゼ,チロシンヒドロキシラーゼ) の遺伝子発現分析 変異性ギャングリオンアングレンのアングレンの遺伝子発現分析
主要な成果:
- Phox2b欠乏症は,自律的反射回路に関与する頭蓋骨の感受性カンジリアを含むすべての自律性カンジリアの形成と退化に失敗する.
- Phox2bは,GDNF受容体サブユニットRetの発現と,発達中の腸内および交感神経系におけるMash1の発現を維持するために不可欠です.
- 変異したギャングリオンアングレンは,ドーパミン-β-ヒドロキシラーゼとチロシンヒドロキシラーゼの遺伝子を発現することができないため,Phox2bがノラドレナゲン現象型を調節する役割を示す.
結論:
- Phox2bは,脊椎動物の自律性ガンジリアの適切な発達,形成,生存に不可欠である.
- Phox2bは,GDNFシグナル伝達とMash1発現を含む重要な分子経路を調節し,自律神経生成に不可欠です.
- Phox2bは,自律神経細胞におけるノラドレナジック現象型の獲得と維持を制御する.
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