人間の血液中の主要な1型インターフェロン産生細胞の性質
F P Siegal1, N Kadowaki, M Shodell
1Saint Vincents Hospital and Medical Center, New York, NY 10011, USA.
Science (New York, N.Y.)
|June 12, 1999
まとめ
科学者は,天然インターフェロン産生細胞 (IPC) を珍しいタイプのデンドリット細胞前駆体 (pDC2) として特定しました. これらのpDC2sは重要なエフェクター細胞であり,ウイルスおよび腫瘍の脅威と戦うために大量のインターフェロンを生成します.
科学分野:
- 免疫学 免疫学とは
- 細胞生物学 細胞生物学
- ウイルス学 ウイルス学 ウイルス学
背景:
- インターフェロン (IFN) は,抗ウイルス免疫における重要なサイトカインです.
- 自然にIFNを生成する細胞 (IPC) は希少で,分離が困難で,アポトーシスに罹患しやすい.
- IPCはCD4およびMHCクラスIIを発現しますが,特定の系統マーカーがありません.
研究 の 目的:
- 人間の血液中の難解な天然のIFN生成細胞 (IPC) を特定し,特徴づけること.
- 重要なIFN生産に責任を負う特定の細胞タイプを決定する.
主な方法:
- 稀な血液細胞の分離と浄化.
- 細胞表面マーカー (CD4,CD11c) を使用したフェノタイプの特徴付け.
- 微生物の脅威後のIFN生産能力の評価.
主要な成果:
- 浄化されたIPCは,CD4 (((+)) CD11c-型2型デンドリット細胞前駆体 (pDC2s) として識別されました.
- pDC2sは,非常に高いIFN生成を示した (他の血液細胞の200〜1000倍).
結論:
- pDC2sは,ヒトの血液中の主要な天然のIFN生成細胞である.
- これらの細胞は,ウイルスおよび抗腫瘍反応に対する天生的免疫における重要な効果細胞です.
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