サイトネーム:ドロソフィラのイメージナルディスクの主要なシグナルセンターに投影する細胞プロセス
F A Ramírez-Weber1, T B Kornberg
1Department of Biochemistry and Biophysics, University of California, San Francisco 94143, USA.
Cell
|June 15, 1999
まとめ
ドロソフィラの翼円盤細胞は,シグナリングセンターと通信するために,サイトネームと呼ばれる薄いアクチンベースの拡張子を使用します. マウス細胞でも見られるこれらの投影は,遠距離細胞伝達におけるサイトネームの役割を示唆する.
科学分野:
- 発達生物学 発達生物学について
- 細胞生物学 細胞生物学
- 分子生物学は分子生物学である.
背景:
- ドロソフィラの翼形状円盤の発達は,前/後部コンパートメント境界からのシグナリングに依存しています.
- 細胞間のコミュニケーションのメカニズムを理解することは,発達過程において極めて重要です.
研究 の 目的:
- 翼円盤の発達中の信号伝送における細胞拡張の役割を調査する.
- これらの拡張が種間で保たれているかどうかを判断する.
主な方法:
- 培養ドロソフィラの翼イメージナルディスク細胞とマウスの肢芽細胞.
- 顕微鏡を用いて細胞の投影 (細胞膜) を観察する.
- 特定の細胞共同培養と成長因子でシトネーム形成を誘導する.
主要な成果:
- ドロソフィラの翼円盤細胞は,前後シグナルセンターに向かって投影する薄い,アクチンベースの拡張 (サイトネーム) を形成します.
- サイトネームの形成は,シグナル伝達細胞または線維芽細胞成長因子に近接することで誘発される可能性があります.
- 培養中のマウスの足肢芽細胞でも同様の投影が観察されました.
結論:
- サイトネームは,細胞間のコミュニケーションに関与する保存された細胞構造である.
- これらの投影は,無脊椎動物と脊椎動物の両方の発達プロセスに不可欠な長距離信号伝達を媒介する可能性があります.
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