人における心房細動が心房収縮機能に与える短期的な影響

E G Daoud¹, P Marcovitz, B P Knight

¹Division of Cardiology, Department of Internal Medicine, University of Michigan Hospital, Ann Arbor, Michigan, USA.

Circulation

|June 15, 1999

まとめ

心房細動 (AF) の短いエピソードは,心臓転換後の左心房付属体 (LAA) の機能を損なう可能性があります. ヴェラパミル治療は,このAF誘発の収縮機能不全を弱める可能性があります.

科学分野:

心臓病学心臓病学
電気生理学電気生理学
心臓生理学心臓生理学

背景:

動脈動 (AF) の変換は,心房麻痺と関連しています.
短いAFエピソードが左心房付属体 (LAA) の排気速度に及ぼす直接的な影響は不明である.

研究の目的:

短いAFエピソードが左心房機能に影響するかどうかを評価する.
ベラパミルが,左心房機能に対するAFの効果を修正できるかどうかを判断する.

主な方法:

トランスエゾファゲアルエコーカルディオグラフィは,電気生理学的処置を受けた19人の患者のLAAの排出速度を測定した.
AFは,約15分間,急速な右心房ペースを介して誘発されました.
ヴェラパミルの前治療は,患者のサブセットに投与されました.

主要な成果:

AF心臓転換後,LAAの排気速度が著しく低下した (P=0.02),しかし3分以内に回復した.
AF後,空き速度の平均9.7%の減少が観察されました.
ヴェラパミルの前処置は,AF後の空化速度の有意な減少を防止しました (P=0.08).

結論:

短いAFエピソードでさえ,心臓転換後の一時的な心房収縮機能障害を引き起こす可能性があります.
この機能障害はベラパミルに敏感で,潜在的にカルシウム媒介のようです.
心房機能の急速な回復は,一時的なメカニズムを示唆しています.

さらに関連する動画

07:09

A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs

Published on: February 18, 2022

07:18

Mouse Cardiac Arrest Model for Brain Imaging and Brain Physiology Monitoring During Ischemia and Resuscitation

Published on: April 14, 2023

関連する概念動画

01:14

Decreased pulse rate

Bradycardia is a medical condition in which the heart rate is slower than normal. It occurs when the heart's natural pacemaker, the sinus node, generates slower electrical impulses than the standard rhythm. In adults, bradycardia is diagnosed when the pulse rate falls below 60 beats per minute, indicating a deviation from the normal heart rate range.
There are specific risk factors that can elevate the likelihood of developing bradycardia. Advanced age is a significant factor, with bradycardia...

01:30

Factors Influencing Heart Rate

The heart rate, or pulse rate, is a vital indicator of cardiovascular health. It reflects the number of times the heart beats per minute. Various physiological and environmental factors influence heart rate, increasing or decreasing cardiac output. Understanding these factors is crucial for assessing heart function and identifying potential health issues.
Let us explore the significant factors affecting heart rate, including age, body temperature, posture, acute pain, chemical influences,...

01:22

Autonomic Nervous System

The autonomic nervous system (ANS) is a critical component of the peripheral nervous system, primarily responsible for regulating involuntary bodily functions and maintaining homeostasis. It functions in tandem with the central nervous system (CNS) to seamlessly coordinate various physiological processes without the need for conscious control.
The ANS comprises two main divisions: the sympathetic and parasympathetic divisions. These divisions function antagonistically to maintain a dynamic...

01:31

Regulation of Heart Rates

The regulation of heart rate is a complex process controlled by the autonomic nervous system (ANS), hormonal influences, and intrinsic cardiac mechanisms. The ANS has two main components: the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS).
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...

01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...

01:17

Other Factors Affecting Respiration Centers

Breathing is primarily an involuntary activity regulated by the brainstem respiratory centers. However, it can also be consciously controlled, allowing us to hold our breath or take deeper breaths when needed. This voluntary control is facilitated by the cerebral motor cortex, which bypasses the medullary centers to stimulate the respiratory muscles directly.
However, the ability to hold one's breath voluntarily is not limitless. When the CO2 concentration in the blood reaches a critical level,...

関連する実験動画