自閉症と麻疹,疹,赤血球のワクチン:因果関係に関する流行病学的証拠はない
B Taylor1, E Miller, C P Farrington
1Department of Community Child Health, Royal Free and University College Medical School, University College London, UK.
Lancet (London, England)
|June 22, 1999
まとめ
この研究では,麻疹,うんざり,赤血球 (MMR) ワクチンが自閉症を引き起こす証拠は見つかりませんでした. 大規模な疫学調査は,MMRワクチン接種と自閉症診断の間のリスクの増加や時間的関連性を明らかにしなかった.
科学分野:
- エピデミオロジー エピデミオロジー
- ワクチン学 ワクチン学
- 発達小児科 発達小児科
背景:
- 麻疹,うんざり,赤血球 (MMR) ワクチンと自閉症の間の潜在的な因果関係を調査しました.
- ワクチンの安全性や神経発達障害に関する公衆衛生上の懸念に対処した.
研究 の 目的:
- MMRワクチン接種と自閉症の発生率または診断の間に関連性があるかどうかを判断する.
- イギリスでMMRワクチンが導入された後の自閉症診断の傾向を分析する.
主な方法:
- イギリスのノース・テムズの498人の自閉症児を対象とした疫学研究.
- ワクチン接種状況とタイミングを評価するために,ワクチン接種データと臨床記録をリンクした.
- MMRワクチン接種後の自閉症発症の時間的なクラスタリングを調査するために,ケースシリーズの方法を使用しました.
主要な成果:
- 1988年にMMRワクチンが導入された後,自閉症発生傾向の変化は観察されなかった.
- 診断時の年齢の違いは,18ヶ月前にまたは後にワクチン接種された子供,または未ワクチン接種の子供にはありません.
- MMRワクチン接種と自閉症の発症,発達逆行,または親の懸念との間に時間的な関連は見つかりませんでした.
結論:
- 研究の結果は,MMRワクチンと自閉症の間の因果関係を支持していません.
- 潜在的な関連性がある場合,非常にまれで,この大きなサンプルでは検出できません.
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