結核の治療後に全血清IgEの低下
J F Adams1, E H Schölvinck, R P Gie
1Centre for Molecular and Cellular Biology and Department of Medical Biochemistry, University of Stellenbosch Medical School, Tygerberg, South Africa.
Lancet (London, England)
|June 22, 1999
まとめ
結核感染症は,強い免疫グロブリンE (IgE) 反応を防ぐことはできません. 結核の治療に成功すると,IgEレベルを低下させ,免疫応答の調節を示します.
科学分野:
- 免疫学 免疫学とは
- 感染症 感染症は感染症です.
- アレルギー研究 アレルギー研究
背景:
- マイコバクテリウム結核感染症は1型免疫反応を誘発する.
- 腸寄生虫は,2型免疫反応を誘発する.
- 1型と2型の免疫反応は,互いに抑制することが知られている.
研究 の 目的:
- Mycobacterium tuberculosisの感染が血清IgEをダウンレギュレーションするかどうかを調査する.
- 結核とIgEレベルとの関係を決定する.
主な方法:
- 南アフリカで37人の対照群と33人の青年の結核患者で実施した前向きな研究.
- 計測された全血清IgE,アスカリス特異IgE,アレルゲン特異IgE.
- 細胞媒介免疫を評価するためにマントックス皮膚検査を行った.
主要な成果:
- 治療前の結核患者の総IgEは,対照群と比較して高かった.
- 結核治療の成功後にIgEレベルが著しく低下した.
- アスカリスに特異的なIgEは,治療前の患者で上昇し,治療後の患者で減少しました.
- 結核素濃縮は,患者におけるIgEレベルと逆相関を示した.
結論:
- マイコバクテリウム結核感染症は,有意なIgE応答と互換性があります.
- 結核治療の成功は,IgEのダウンレギュレーションにつながります.
- このダウンレギュレーションは,おそらく1型免疫応答の強化によるものです.
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