QT間隔は,正常な被験者の2つの長いQT症候群の位置と関連しています

A Busjahn¹, H Knoblauch, H D Faulhaber

¹Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charité, Humboldt University of Berlin, Germany.

Circulation

|June 22, 1999

まとめ

双子の速度修正QT間隔 (QTc) の遺伝子解析により,QTcの変異に関連した特定の遺伝子ロキが特定されました. この研究は,心臓リズム障害に影響を与える遺伝因子の理解を前進させる.

科学分野:

心血管遺伝学心血管遺伝学
人間の遺伝学人間の遺伝学
分子生物学は分子生物学である.

背景:

率修正QT間隔 (QTc) は遺伝する特徴です.
QTcに影響を与える遺伝子を特定することは,不規則なリズムを理解するために重要です.
以前の研究で,QTc.の遺伝性が確認された.

研究の目的:

QTc変異の遺伝的根拠を調査する.
QTc.に影響を与える定量的な特性の位置 (QTLs) を特定する.
既知の長QT症候群 (LQT) 遺伝子とQTc.との間のリンクをテストする.

主な方法:

66組の双胞胎双子とその両親のシブラペア分析を用いた.
LQT遺伝子位置付近のQTcとマイクロサテライトマーカーの間のリンク分析を行った.
QTc,QRS持続時間,QRS/T波軸における遺伝的多様性を評価した.

主要な成果:

LQT1 (11染色体) とLQT4 (4染色体) のQTcとロシとの間に有意な関連性が見つかりました.
QTcとLQT2,LQT3またはLQT5のロケ地との有意な関連は観察されなかった.
QTc,QRS持続時間,QRS/T波軸の遺伝的変異が特定され,女性は男性より長いQTcを示した.

結論:

QTcのための識別されたQTLは,LQT遺伝子の変異が心拍不良のリスクに貢献することを示唆しています.
研究結果は,QTc変異に関連した特定の遺伝的位置 (LQT1,LQT4) を強調しています.
この研究は,心臓リズム障害に対する遺伝的予備性に関するさらなる調査のための基礎を提供します.

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