静的運動中のシヌス節の調節に対する筋肉のメタボレフレクスの貢献:心拍数変動のスペクトル解析からの洞察
F Iellamo1, P Pizzinelli, M Massaro
1Dipartimento di Medicina Interna, Università di Roma "Tor Vergata," Rome, Italy. iellamo@med.uniroma2.it
Circulation
|July 7, 1999
まとめ
筋肉のメタボレフレクスは,交感活性化を通じて運動中の心拍数調節を助けます. 動脈のバロレフレクスのメカニズムは,筋肉のメタボレフレクスの刺激が持続しても,運動後の心拍の回復を説明します.
科学分野:
- 心血管生理学 心血管の生理学
- 自律神経系の規制について
- 運動生理学 運動生理学
背景:
- 現在の理解では,中央コマンドが静的運動中のパラシンパティック撤退を通じて主に心拍数 (HR) に影響することを示唆しています.
- 筋肉のメタボレフレクスは,同情性血管収縮を通してのみ血圧 (BP) を上昇させると考えられており,BPは高くなっていながらHRは運動後の回復します.
- この研究では,HRの調節におけるメタボレフレクスの役割と,運動後のHR回復におけるバロレフレクスの関与を調査しています.
研究 の 目的:
- 筋肉のメタボレフレックスが,静的運動中の心拍数調節に,交感活性化を介して貢献するかどうかをテストする.
- 運動後の筋肉のイシュケミア中に動脈バロレフレクスが心拍の回復に影響するかどうかを判断する.
主な方法:
- 11人の健康な男性は,静的な足の伸縮 (SLE) を実行し,その後,足の循環停止 (ALC) を実行しました.
- 心拍の変動性 (HRV) のスペクトル解析により,自律的なHR調節が評価されました.
- 自発的なバロレフレクスの方法では,心臓周期のバロレフレクスの制御を評価した.
主要な成果:
- 静的な足の伸縮はHRVの低周波成分を増加させ,交感性活性化を示し,足の循環が停止したときに持続した.
- HRVの正常化された高頻度成分は,SLEでは減少し,ALCでは正常化しました.
- バロレフレクスの敏感性は,SLEでは低下し,ALCでは回復し,高血圧とHRの回復と一致しました.
結論:
- 筋肉のメタボレフレクスは,交感神経系の活性化を通じて静的運動中に心拍数調節に貢献します.
- 進行中の交感刺激にもかかわらず,運動後のブラディカルディアは,交感ドライブを上回るパラシンパティックアウトフローのバロレフレクスの媒介による増加による可能性が高い.
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