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1000人の無症状のボランティアの脳磁気共鳴画像の偶然の発見
G L Katzman1, A P Dagher, N J Patronas
1Diagnostic Radiology Department, National Institutes of Health, Bethesda, MD 20892, USA.
JAMA
|July 15, 1999
まとめ
健康な人での脳MRIスキャンでは,18%の症例で予期せぬ異常が明らかになる. 脳腫瘍を含むこれらの偶然の発見のわずかな部分は,緊急の医療を必要とする.
科学分野:
- 神経学 神経学とは
- 放射線学 放射線学
- メディカルイマージング (医学イメージング)
背景:
- 偶然の脳発見に関する以前の研究は,事前に存在する臨床的懸念によって偏っていました.
- 本当に健康な集団における予期せぬ異常の有病率は未研究のままである.
研究 の 目的:
- 健康で無症状の集団における脳MRIスキャンにおける偶然の発見の発生率を決定する.
- 選択バイアスなしに予期せぬ異常率を評価する.
主な方法:
- 1000人の健康なボランティア (3歳から83歳) の脳MRIスキャンを遡及的に分析した.
- 参加者は,医師の検査と履歴を通じて,健康で無症状であることが確認されました.
- 発見は,必要な紹介の緊急性 (なし,ルーティン,緊急,即時) によって分類されました.
主要な成果:
- 脳MRIスキャンの82%は正常でした.
- スキャンの18%は偶然の異常を明らかにした.
- 1.1%の被験者に緊急の紹介が必要であり,少なくとも0.2%が原発性脳腫瘍と特定されました.
結論:
- 症状のない個人は,様々な脳の異常を呈することがあります.
- 健康な集団における偶然の発見は,病気の流行に関する重要なデータを提供します.
- これらの発見の小さな割合は,迅速な医学的評価とさらなる調査を必要とします.
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