末期腎疾患で透析を受けている患者の癌: 国際的な共同研究
P Maisonneuve1, L Agodoa, R Gellert
1Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy. pmaison@ieo.it
Lancet (London, England)
|July 17, 1999
まとめ
末期腎疾患 (ESRD) の患者は,特に若い個体では,全体的にがんのリスクが高くなります. 腎臓や膀などの特定の癌はより一般的であり,おそらくウイルスの要因と腎機能の喪失によるものです.
科学分野:
- ネフロロジーは腎臓科
- 腫瘍学 腫瘍学
- エピデミオロジー エピデミオロジー
背景:
- 以前の研究では,末期性腎疾患 (ESRD) の患者のがん発生率が高くなることが示唆されています.
- 特定の癌の種類や,影響を受ける患者のサブグループについて,不確実性が存在します.
研究 の 目的:
- 移植なしの透析患者の大規模なコホートでがんリスクを調査する.
- 特定のがんや,リスクの増加と関連した患者の人口統計を特定するためです.
主な方法:
- 1980年から1994年の間に透析を受けた83万1,804人のESRD患者のコホートを集めました.
- 癌の発生率は,2,045,035人年における背景集団と比較されました.
主要な成果:
- 全体的ながんリスクは高かった (標準化罹患率1.18).
- 若い患者 (<35歳) は,著しく高いリスクを示した (3.68).
- 腎臓 (3.60),膀 (1.50),内分泌器官がん (2.28) のリスクが高まっている.
結論:
- ESRD患者は,移植後の患者と同様のパターンで,全般的ながんリスクの増加に直面しています.
- 過剰なリスクは,腎臓/尿路疾患とウイルス発がんの感受性に関連しています.
- リスクは若い患者で最も高く,年齢とともに減少します.
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