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バロレフレクスの増幅は,ヒトにおけるシミュレートされた心室動脈低血圧の間に血圧の回復を予測します
M H Hamdan1, J A Joglar, R L Page
1University of Texas, Southwestern Medical Center, Dallas, Texas, USA. hamdan@ryburn.swmed.edu
Circulation
|July 27, 1999
まとめ
より高い動脈バロレフレクスの獲得は,シミュレートされた心室動脈性低血圧 (VT) 中の血圧回復を改善します. この発見は,バロレフレクスの獲得がVT患者における血液動力学的安定性の鍵であることを示唆しています.
科学分野:
- 心血管生理学 心血管の生理学
- 自律神経系の規制について
- 臨床電気生理学 臨床電気生理学
背景:
- 静脈性低心力症 (VT) に対する患者の反応は,似たような心機能不全にもかかわらず,異なる.
- 交感神経活動 (SNA) は静脈動脈療法中に増加し,血液動力学的結果に影響を与えます.
- 動脈バロレフレクスの増加は,VTにおける純交感刺激効果を決定する可能性があります.
研究 の 目的:
- 急速心房ペース (VP) の間に動脈のバルオレフレクスの交感的増益と血圧 (BP) の回復との関係を調査する.
- バロレフレクスの増加が,シミュレートされたVT中に血液動力学的安定性を維持する重要な要因であるかどうかを判断する.
主な方法:
- 電気生理学的研究を受けている14人の患者で測定されたエフェルント筋肉SNA,BP,およびCVP.
- ニトロプルシド注入中に動脈バロレフレクスの増加を評価し,SNAの変化の傾きから静脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈
- VP中の定量化されたBP回復は,平均動脈圧 (MAP) の上昇を最低値から安定状態まで測定することによって測定されます.
主要な成果:
- 動脈バロレフレクスの増加は,VP (r=0.57,P=0.034) 中のMAP回復と正に相関していました.
- 射出分数とバロレフレクスの増加,またはBP回復との間に有意な相関は見つかりませんでした.
- バロレフレクスの増幅が高い患者は,増幅が低い患者と比較して,シミュレートされたVT中にMAPの回復が有意に大きく示されました.
結論:
- 動脈バロレフレクスの増加は,シミュレートされたVT中に血液動力学的安定性に大きく貢献します.
- 個々の患者によるバロレフレクスの知識の獲得は,持続性静脈動症の個別化された治療法を導くことができます.
キーワード:
非プログラム的なものです.さらに関連する動画
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