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左心房のリラクゼーションと左心房のシストリック機能が,左心房貯水池の機能を決定する
P Barbier1, S B Solomon, N B Schiller
1Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, USA.
Circulation
|July 27, 1999
まとめ
左心房貯水器の機能には2つの段階があり,心房収縮,リラックス,そして左心房底下降の影響を受けます. 急性イシュケミアは硬さを高め,貯水器の機能を損なう.
科学分野:
- 心血管生理学 心血管の生理学
- 心臓のメカニズム 心臓のメカニズム
- エコーカルディオグラフィー エコーカルディオグラフィー
背景:
- 左心房 (LA) 貯水池機能の決定因子とその左心房 (LV) 機能への影響は,まだ完全に理解されていません.
- これらの関係を定量化することは,心臓のパフォーマンスを理解するために非常に重要です.
研究 の 目的:
- LA貯水池機能の決定要因とそのLV機能への影響を定量化する.
- LA貯水池の機能とメカニズムに対する急性LV地域性缺血の影響を調査する.
主な方法:
- 誘発されたLVの地域性イシュケミアのオープン心房豚モデルを使用しました.
- 高精度圧力記録 (LV,LA,RV) とLA領域評価のための2Dエコーカルディオグラフィーを使用しました.
- 計算されたLA圧力領域ループ,ドップラー伝達流量,LVタウ,LAリラクゼーション,LA硬さ.
主要な成果:
- 2つの異なるLA貯水池段階を特定した:早期 (LA射出速度とリラックスに依存) と遅い (LVベース降下に依存).
- 急性LVイシュケミアは,LA貯水池面積の変化を大幅に減らし,LAの硬さを増加させた.
- LA貯水池の充填は,心臓の出力量の最も強い予測要因でした.
結論:
- LA貯水池機能は,心房動力学とLVベース運動の影響を受ける初期と後期の相を含みます.
- 急性LV地域性イシュケミアは,LAの硬さを増加させ,LVのベース降下を減少させることで,LA貯蔵庫機能に悪影響を及ぼします.
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