感染症と動脈硬化:新興の機械的パラダイム
1Cardiovascular Research Foundation, Washington Hospital Center, Washington, DC 20010, USA. sxe2@mhg.edu
Circulation
|July 27, 1999
まとめ
感染症は,細胞の変化を引き起こすことによって,動脈硬化に寄与する可能性があります. 動脈硬化のリスクは,感染病原体の数によって増加し,宿主によって異なる.
科学分野:
- 心血管科学 心血管科学
- 感染症免疫学 感染症免疫学
背景:
- 動脈硬化症の発症は複雑で,感染が潜在的要因として浮上している.
- Chlamydia pneumoniaeやcytomegalovirusのような特定の病原体が,動物モデルで動脈硬化症を悪化させることが示されています.
研究 の 目的:
- 伝染病原体と動脈硬化症の発症の関連性を調査する.
- 病原体負荷と宿主の免疫反応が動脈硬化リスクにどのように影響するかを理解する.
主な方法:
- 伝染病原体と動脈硬化に関する既存の調査のレビュー.
- 病原菌と疾患の進行を結びつける動物モデルとヒトの研究からのデータの分析.
主要な成果:
- 感染症剤は,アテロゲネシスをサポートする細胞および分子変化を誘発します.
- 複数の病原体が動脈硬化症に関連しており,リスクは感染の数と相関しています.
- ホストの感受性は,免疫応答の有効性 ( humoral vs. 細胞) と潜在的自己免疫成分によって影響を受け,変化します.
結論:
- 決定的な因果的な証拠は待たされているが,感染が動脈硬化に寄与することを示す証拠がある.
- ホストの免疫応答と病原体負荷は,感染症に関連する動脈硬化症の重要な要因です.
- 仕組みを明らかにし,予防戦略を開発するために,さらなる研究が不可欠です.
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