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関連する概念動画

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Rocky Mountain Spotted Fever01:26

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
Smallpox01:24

Smallpox

Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.
Malaria01:29

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...
American Trypanosomiasis01:22

American Trypanosomiasis

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Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...

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Updated: Jul 7, 2026

Taste Preference Assay for Adult Drosophila
04:31

Taste Preference Assay for Adult Drosophila

Published on: September 8, 2016

アカルボース誘発の汎用性赤血腫マルチフォーム

T Kono, M Hayami, H Kobayashi

    Lancet (London, England)
    |August 7, 1999
    PubMed
    まとめ
    この要約は機械生成です。

    58歳の男性は,糖尿病のためにアカルボスを開始した後,一般的な皮膚発疹と高エオシノフィルの数を発症しました. このアレルギー反応の原因はアカルボースであることが確認されました.

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    Published on: September 8, 2016

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    科学分野:

    • 薬理学 薬理学とは
    • 皮膚科 皮膚科について
    • アレルギーと免疫学

    背景:

    • アカルボースは,2型糖尿病の管理に使用されるアルファ-グルコシダース阻害剤です.
    • 効果的な血糖コントロールは,糖尿病患者において,長期的な合併症を予防するために極めて重要です.

    研究 の 目的:

    • アカルボゼ治療と潜在的に関連している一般的な多形赤血腫とエオシノフィリアの症例を報告する.
    • アカルボースと観察された有害反応の間の因果関係を確認するために.

    主な方法:

    • 糖尿病の患者は,アカルボース300mgを1日1回と開始しました.
    • 多形赤血腫およびエオシノフィリアの臨床および組織学的検査が行われました.
    • アカルボースチャレンジテストは,アレルギー反応を確かめるために実施されました.

    主要な成果:

    • アカルボゼの投与開始から13日後に発症した汎性赤血腫マルチフォーム.
    • 血液および組織エオシノフィリアが検出されました.
    • アカルボースチャレンジテストは,臨床的にも,組織学的にもアレルギー反応を確認した.

    結論:

    • アカルボースは,エオシノフィリアのある汎用性赤血腫マルチフォームとして現れる過敏反応を誘発する可能性があります.
    • このケースは,このような有害事象の潜在的な原因としてアカルボースを考慮することの重要性を強調しています.
    • ヒストロジカル確認とチャレンジテストは,薬物誘発過敏症の診断に価値があります.