増加したリポプロテイン (a) は,小児期の静脈性血栓塞栓症の重要な危険因子です
U Nowak-Göttl1, R Junker, M Hartmeier
1Department of Pediatrics, Laboratory Medicine, Westfälische Wilhelms-Universität, Münster, Germany.
Circulation
|August 18, 1999
まとめ
増加したリポプロテイン (a) [Lp (a) ]レベルは,子供の静脈性血栓塞栓症の重要な危険因子です. Lp (a) の測定は,これらのイベントの子どもをスクリーニングするために非常に重要です.
科学分野:
- 心血管遺伝学 心血管遺伝学
- 小児性トランボシス
- 脂質代謝についてです.
背景:
- 脂質タンパク質 (Lp) のレベルは遺伝的に決定され,動脈硬化症と関連しています.
- 静脈性血栓塞栓性疾患,特に小児におけるLp (a) の役割は十分に特徴づけられていない.
- 確立された血栓形成の危険因子には,血液凝固と線維分解を調節するタンパク質が含まれています.
研究 の 目的:
- 子どもにおける静脈性血栓塞栓性疾患の危険因子としてのLp (a) の役割を調査する.
- 静脈血栓症のリスクに対するLp (a) と他の血栓性要因の組み合わせた効果を評価する.
- アポリポプロテイン (アポリポプロテイン) [アポリポプロテイン (アポリポプロテイン) ]アイソフォームのサイズとLp (アポリポプロテイン (アポリポプロテイン) レベル/血栓塞栓リスクとの関係を決定する.
主な方法:
- 血清Lp(a),脂質,タンパク質C,タンパク質S,および抗トロンビン濃度が測定されました.
- Apo(a) 異形体のサイズと因子V:Q(506) 変異の存在を分析した.
- 静脈血栓症の186人の子どもと186人のマッチングした対照群 (新生児から18歳まで) を研究した.
主要な成果:
- 静脈血栓症の小児は,平均Lp (a) 濃度 (19対4.4mg/dL) が有意に高かった.
- Lp (a) 濃度>30 mg/dLは,血栓塞栓性イベントの7.2倍以上のリスクをもたらしました.
- V因子 (Q506) 変異,タンパク質C,抗血栓欠乏は独立した危険因子であったが,Lp (a) 値が上昇すると,これらのリスクがさらに増加した.
結論:
- 血清Lp (a) >30 mg/dLは,小児期の静脈血栓塞栓症の重要なリスク因子である.
- Lp (a) の測定は,小児静脈性血栓塞栓性イベントのエチオロジックスクリーニングに組み込まれなければなりません.
- Apo(a) アイソフォームの大きさは,Lp(a) レベルと血栓栓塞栓のリスクと逆関係にあります.
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