長期記憶の貯蔵基盤である脳回路の時間依存的な再編成

B Bontempi¹, C Laurent-Demir, C Destrade

¹Laboratoire de Neurosciences Cognitives, CNRS UMR 5807, Université Bordeaux I, Talence, France. b.bontempi@neurocog.u-bordeaux.fr

Nature

|August 24, 1999

まとめ

海馬は新しい長期記憶の形成に不可欠ですが,遠隔記憶は時間とともに再編成されます. この研究では,脳の回路がヒポカンプスから脳皮質に移動し,記憶を永続的に保存することを示しています.

科学分野:

神経科学は神経科学である.
認知神経科学とは
記憶の研究記憶の研究

背景:

長期記憶の貯蔵における海馬の役割は,特に遠隔記憶回収の必要性について議論されています.
前回の研究では,海馬の病変を用いて,記憶のリコール中に海馬が無傷であるときの役割を評価することができなかった.

研究の目的:

健全な脳における長期記憶記憶のための脳回路の一時的な再編成を調査する.
時間の経過とともに海馬と皮質の代謝活動の変化を,記憶保持のために調べる.

主な方法:

マウスにおける (14C) 2-デオキシグルコースの摂取量による非侵襲的機能脳画像を用いた.
空間差別のタスク中に異なる保持間隔 (5日と25日) でマッピングされた領域の脳代謝活動.

主要な成果:

ヒポカンパの代謝活動は,より長い保持間隔 (25日対5日) により減少した.
海馬の活動と記憶力の相関は,時間の経過とともに減少した.
特定の皮質領域で代謝活動の増加が観察され,その徴募が示唆されました.

結論:

長期記憶の貯蔵には,神経回路の時間依存的な再編成が含まれます.
海馬は一時的な役割を果たし,記憶の表現を長期保存のために新皮質に転送することを促進します.
このプロセスは,永続的な記憶の痕跡を確立するために,海馬形成と皮質領域の相互作用を伴う.

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