クラミジア肺炎感染症と早期の無症状の頸動脈動脈硬化症
H S Markus1, M Sitzer, D Carrington
1Department of Clinical Neuroscience, King's College School of Medicine,Institute of Psychiatry, London, UK. h.markus@iop.kcl.uk
Circulation
|August 24, 1999
まとめ
この研究では,クラミジア肺炎感染症と,インティマ・メディアの厚さのような早期動脈硬化マーカーとの間に関連性がないことが判明しました. より高度な頸動脈疾患との潜在的な関連を調べるためにさらなる研究が必要です.
科学分野:
- 心血管科学の研究について
- 感染症 感染症は感染症です.
- 医療診断 医療診断
背景:
- 慢性的なクロミジア肺炎感染症は,動脈硬化症の発症に疑われる.
- 初期の動脈硬化症におけるC.pneumoniaeの役割は不明である.
- 頸動脈内側介質の厚さ (IMT) とプラークの評価は,早期の動脈硬化に関する洞察を提供します.
研究 の 目的:
- クラミジア肺炎感染と早期動脈硬化症との関連を調査する.
- C.pneumoniaeの陽性性が,頸動脈のIMTまたは斑塊の存在と相関するかどうかを判断する.
主な方法:
- 超音波画像は,983人の (30〜70歳) 個人で,動脈のIMTとプラークの厚さを測定しました.
- Chlamydia pneumoniaeのIgAとIgGの抗体タイターが測定されました.
- 血清陽性と動脈の測定値との関連性を分析し,リスク要因を調整した.
主要な成果:
- C.pneumoniaeのIgAまたはIgGの血清陽性性と大動脈内膜の厚さ,またはプラークの存在との間に有意な関連性は見つかりませんでした.
- IgA血清陽性と>50%の頸動脈狭窄症との潜在的な関連が観察されましたが,心臓血管リスク因子を調整した後は重要性が失われました.
- C. pneumoniaeの血清陽性と炎症マーカー (線維素素,C反応性タンパク質,白血球数) の間には相関が認められなかった.
結論:
- C. pneumoniaeの感染の血清学的証拠は,初期の動脈硬化症と関連していません.
- 先進性動脈硬化症との関連の可能性は,関連する集団でのさらなる調査を正当化します.
- C.pneumoniaeの感染は,慢性的な全身性炎症状態を誘発しないようです.
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