神経免疫性尾炎は,神経免疫性尾炎である
P Di Sebastiano1, T Fink, F F di Mola
1Department of Visceral and Transplantation Surgery, University of Berne, Inselspital, Switzerland.
Lancet (London, England)
|August 28, 1999
まとめ
物質P (SP) と血管活性腸ペプチド (VIP) 神経を含む神経増殖は,炎症のない付属体の腹痛を引き起こす可能性があります. これは,神経免疫性虫炎と呼ばれる独特な状態を示唆しています.
科学分野:
- 胃腸内科 胃腸内科
- 神経科学は神経科学である.
- 免疫学 免疫学とは
背景:
- 手術で摘出した臓の15~25%は,臓炎の疑いがあるにもかかわらず,組織学的炎症を示さない.
- これらの症例における痛みの病因は不明である.
- 慢性炎症では神経ペプチドの変化が観察され,ペプチダーギー内置の変化の調査を促しています.
研究 の 目的:
- 虫垂炎における物質P (SP),血管活性腸ペプチド (VIP),成長関連タンパク質-43 (GAP-43) のペプチダーギー内置の変化を調査する.
- 炎症のない尾痛における神経免疫相互作用の役割を調査する.
主な方法:
- 免疫サイトケミストリーは,SP,VIP,GAP-43を分析するために,31の附属体 (16急性,15非急性) と16の対照群で免疫サイトケミストリーが使用されました.
- デジタル化された形態測定は,SPの免疫染色体の密度を評価した.
- サンプルは,急性盲腸炎,非急性盲腸炎,または正常に分類されました.
主要な成果:
- 成長関連タンパク質-43 (GAP-43) の発現は,非急性付炎の症例では上昇した.
- SPおよびVIPの免疫反応性神経の量は,対照群および急性盲腸炎と比較して,非急性盲腸の粘膜層で著しく高かった.
- SP/VIP神経と,外側のリンパ毛細部領域のリンパ性細胞との間には,密接な空間的関係が見られた.
結論:
- SPとVIPの神経伝達物質の増加は,付属体の神経増殖とともに,急性炎症がない場合でも,右腹痛に寄与する可能性があります.
- この発見は",神経免疫性盲腸炎"を,独特の病理学的な実体として示唆しています.
- これは,付属体の病理学における神経系と免疫系との相互作用を強調しています.
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