関連する実験動画

Updated: Jul 6, 2026

Nanomanipulation of Single RNA Molecules by Optical Tweezers
06:59

Nanomanipulation of Single RNA Molecules by Optical Tweezers

Published on: August 20, 2014

コドン-アンチコドンヘリクスをリボソームRNAによって認識する

S Yoshizawa1, D Fourmy, J D Puglisi

  • 1Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305-5126, USA.

Science (New York, N.Y.)
|September 11, 1999
PubMed
まとめ

リボソームは,転送RNA (tRNA) とメッセンジャーRNA (mRNA) のマッチングをチェックすることで,正確なタンパク質合成を保証する. リボソームRNAにおけるアデニンの改変は,この重要なコドン-アンチコドンの認識プロセスにおける重要な相互作用を明らかにする.

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Transfer RNA Synthesis02:36

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Transfer RNA Synthesis02:36

Transfer RNA Synthesis

One of the unique features of tRNA is the presence of modified bases. In some tRNAs, modified bases account for nearly 20% of the total bases in the molecule. Altogether, these unusual bases protect the tRNA from enzymatic degradation by RNases.
Each of these chemical modifications is carried by a specific enzyme, post-transcription. All of these enzymes have unique base and site-specificity. Methylation, the most common chemical modification, is carried by at least nine different enzymes, with...
Nonsense-mediated mRNA Decay02:27

Nonsense-mediated mRNA Decay

The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
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