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Updated: May 5, 2026

Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies
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SOCS1欠乏症はリンパ球に依存した生後死亡率を引き起こす

J C Marine1, D J Topham, C McKay

  • 1Howard Hughes Medical Institute, and Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

Cell
|September 18, 1999
PubMed
まとめ

サイトカインシグナル伝達1 (SOCS1) 抑制剤の欠乏は,免疫系の調節不良により,マウスの早期死亡を引き起こします. インターフェロン-ガンマ (IFNγ) またはRAG2を排除すると,リンパ球を強調して,この致死性を防止します.

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