酸化窒素は,衰弱した人間の心臓におけるミトコンドリアの呼吸を調節する
K E Loke1, S K Laycock, S Mital
1Department of Physiology, New York Medical College, Valhalla, NY, USA.
Circulation
|September 24, 1999
まとめ
酸化窒素 (NO) は,衰弱した人間の心臓の組織呼吸に影響を与えます. 内生性および外生性NOの両方が,酸素消費を調節し,NOを強調する.
科学分野:
- 心血管生理学 心血管の生理学
- ミトコンドリアの呼吸
- 酸化窒素シグナリング
背景:
- 人間の心筋不全は,代謝機能の変化を示します.
- 心不全における組織呼吸の調節における酸化窒素 (NO) の役割は完全に理解されていません.
研究 の 目的:
- 人間の心筋不全における酸化窒素 (NO) によって組織呼吸の調節を調査する.
- 心不全における酸素消費に対する内生性および外生性NOの影響を決定する.
主な方法:
- エクスプラントされた心臓から採取したヒト心筋組織サンプルを使用した.
- 組織の酸素消費量は,クラーク型酸素電極を使用して測定されました.
- ブラジキニン,アムロディピン,ラミプリラット,チオルファン,およびNOを放出する化合物の効果は,NO合成酵素の阻害の前後に評価されました.
主要な成果:
- ブラジキニン,アムロディピン,ラミプリラット,チオルファンは心筋の酸素消費を低下させた.
- これらの減少は,NO合成酵素の阻害によって著しく軽減され,NOの関与を示した.
- 外因的なNO放出化合物も,NO合成阻害とは無関係に,酸素消費を減少させた.
結論:
- NOによる酸素消費の調節は,人間の心筋不全で保存されます.
- キニン分解の抑制は,心不全におけるミトコンドリア呼吸の調節に不可欠である.
- 内生性および外生性両方のNOは,心筋組織呼吸に役割を果たします.
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