大人の急性腎不全で神経学的関与は,麻疹ウイルスの隔離と関連しています

N S Wairagkar¹, B V Gandhi, S M Katrak

¹National Institute of Virology, Pune, India. icmrniv@icmrniv.ren.nic.in

Lancet (London, England)

|September 29, 1999

まとめ

麻疹ウイルスは急性腎不全を引き起こし,発疹のない成人では神経学的症状を引き起こしました. この診断は,非典型的なプレゼンテーションを強調して,麻疹の除去プログラムにとって非常に重要です.

科学分野:

ウイルス学ウイルス学ウイルス学
神経学神経学とは
ネフロロジーは腎臓科

背景:

インドのムンバイで神経学的関与による急性腎不全の成人3症例を調査した.
神経学的および腎臓症状のエチオロジーは当初不明でした.

研究の目的:

成人患者における急性腎不全と神経学的症状の原因を特定する.
この異常なプレゼンテーションに関連した臨床および検査結果について説明します.

主な方法:

3人の成人患者の症例報告と検査結果を分析した.
IgM ELISAを用いた麻疹を含むウイルス感染症に対する血清と脳脊髄液の検査,Vero-cell培養におけるウイルス分離,および免疫光分析.

主要な成果:

発熱,嘔吐,腎不全,顔の弱さ,聴覚障害,麻痺,呼吸器不全を呈した患者で,典型的な発疹はなかった.
血中の尿素窒素とクレアチニンの上昇,高タンパク質と脳脊髄液の胞症,腎臓生検のインタースティシャル腎炎が観察されました.
血清と脳脊髄液のIgM抗体による麻疹ウイルス感染が確認され,臨床サンプルから麻疹ウイルスが分離されました.

結論:

発疹のない成人における麻疹ウイルスに関連した神経学的関与による急性腎不全の異常な症状が確認されました.
発見は,世界的に麻疹撲滅プログラムの開発と戦略に影響を与える可能性があります.

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