シンガポールの屠殺場労働者の間でニパウイルス感染が流行した

N I Paton¹, Y S Leo, S R Zaki

¹Department of Infectious Diseases, Communicable Disease Centre, Tan Tock Seng Hospital, Singapore. Paton_NIJ@notes.ttsh.gov.sg

Lancet (London, England)

|October 16, 1999

まとめ

ニパウイルス感染症は,シンガポールの屠殺場労働者の脳炎と肺炎を引き起こしました. 磁気共鳴画像は,特徴的な脳損傷を明らかにし,肺の関与は一般的でした.

科学分野:

ウイルス学ウイルス学ウイルス学
神経学神経学とは
感染症感染症は感染症です.

背景:

1999年3月,シンガポールの屠殺場労働者の間で脳炎と肺炎の発生が発生しました.
この研究では,罹患者の臨床表現と調査結果について説明しています.

研究の目的:

ニパウイルス感染症の臨床的特徴と診断結果を記述する.
ニパウイルス脳炎に関連した特徴的な放射線学的発見を特定する.

主な方法:

罹患患者の臨床および検査データの体系的なレビュー.
ELISAを用いた血清におけるニパウイルス固有のIgM抗体の検出.
リバーストランスクリプトーゼPCRによる脳脊髄液 (CSF) と組織サンプルにおけるニパウイルスRNAの識別.

主要な成果:

急性ニパウイルス感染が確認された患者は11人,ニパウイルスは1人の死亡者で確認された.
一般的な症状には,発熱,頭痛,眠気などがあり,8人の患者は脳炎,3人の患者は非典型性肺炎を発症した.
MRIは,脳炎患者の白質の焦点病変を明らかにした;アシクロビールで治療された9人のうち8人が生き残った.

結論:

ニパウイルス感染症は脳炎の原因であり,明確なMRI発見があります.
肺の関わりは頻繁であり,疾患は非典型性肺炎として表れることがあります.

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