Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Types of Genetic Transfer Between Organisms02:18

Types of Genetic Transfer Between Organisms

Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved DNA...
The Central Dogma01:20

The Central Dogma

The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
Types of Genetic Transfer Between Organisms02:18

Types of Genetic Transfer Between Organisms

Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.
Cloning of Dolly the Sheep01:08

Cloning of Dolly the Sheep

The first successfully cloned mammal was Dolly, a sheep, born on 5th July 1996 at Roslin Institute, Scotland. The cloned sheep was named after the American singer Dolly Parton. Dolly lived for seven years and died of respiratory complications, which is speculated to be due to the actual age of her DNA. Because the DNA in cloned cells belongs to an older individual,  the cloned individual’s life expectancy may be affected. Indeed, analysis of Dolly’s DNA revealed shorter telomeres than other...

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Genome Wide Conditional Mouse Knockout Resources.

Drug discovery today. Disease models·2024
Same author

Cellular characterisation of the GCKR P446L variant associated with type 2 diabetes risk.

Diabetologia·2011
Same author

Analysis of yeast artificial chromosome clones.

Methods in molecular biology (Clifton, N.J.)·2011
Same author

A role for coding functional variants in HNF4A in type 2 diabetes susceptibility.

Diabetologia·2010
Same author

A common nonsense mutation in EphB2 is associated with prostate cancer risk in African American men with a positive family history.

Journal of medical genetics·2005
Same author

Agouti-related protein promoter variant associated with leanness and decreased risk for diabetes in West Africans.

International journal of obesity (2005)·2005

関連する実験動画

Updated: Jul 18, 2026

A Noninvasive Hair Sampling Technique to Obtain High Quality DNA from Elusive Small Mammals
07:40

A Noninvasive Hair Sampling Technique to Obtain High Quality DNA from Elusive Small Mammals

Published on: March 13, 2011

哺乳類の遺伝子コレクション

R L Strausberg1, E A Feingold, R D Klausner

  • 1National Cancer Institute, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Science (New York, N.Y.)
|October 16, 1999
PubMed
まとめ

哺乳類遺伝子コレクション (MGC) プロジェクトは,研究者のために,一般にアクセス可能な,完全な補完的なDNA (cDNA) 資源を作成しています. このイニシアチブは,科学的進歩のために,哺乳類の遺伝子配列とクローンの包括的なセットを提供することを目的としています.

科学分野:

  • ゲノミクスゲノミクスとは
  • 分子生物学は分子生物学である.
  • バイオテクノロジー バイオテクノロジー

背景:

  • 完全な補完的なDNA (cDNA) 資源の必要性は,哺乳類の遺伝子機能を理解する上で極めて重要です.
  • 既存のリソースは不完全である場合や,全長オープン・リーディング・フレーム (ORF) が欠けている場合がある.

研究 の 目的:

  • 哺乳類遺伝子収集 (MGC) プロジェクトを設立する.
  • 人間および他の哺乳類の全長ORF配列およびクローンの完全なセットを作成し,公衆にアクセスできるようにする.
  • 必須の遺伝資源で研究コミュニティを支援する.

主な方法:

  • 図書館の生産と建設.
  • コンプリメンタリーDNA (cDNA) のハイスループットシーケンシング.
  • データ管理とアクセスのための堅牢なデータベースとリポジトリの開発.
  • シーケンシングと分析のための支援技術の進歩.

主要な成果:

  • 哺乳類の全長cDNAクローンの貴重なコレクションの生成.
  • これらの遺伝資源の公開可能なデータベースの作成.

さらに関連する動画

Milk Collection Methods for Mice and Reeves' Muntjac Deer
07:34

Milk Collection Methods for Mice and Reeves' Muntjac Deer

Published on: July 19, 2014

Quantification of Circulating Pig-Specific DNA in the Blood of a Xenotransplantation Model
07:34

Quantification of Circulating Pig-Specific DNA in the Blood of a Xenotransplantation Model

Published on: September 22, 2020

関連する実験動画

Last Updated: Jul 18, 2026

A Noninvasive Hair Sampling Technique to Obtain High Quality DNA from Elusive Small Mammals
07:40

A Noninvasive Hair Sampling Technique to Obtain High Quality DNA from Elusive Small Mammals

Published on: March 13, 2011

Milk Collection Methods for Mice and Reeves' Muntjac Deer
07:34

Milk Collection Methods for Mice and Reeves' Muntjac Deer

Published on: July 19, 2014

Quantification of Circulating Pig-Specific DNA in the Blood of a Xenotransplantation Model
07:34

Quantification of Circulating Pig-Specific DNA in the Blood of a Xenotransplantation Model

Published on: September 22, 2020

  • 全長遺伝子配列を必要とする多様な研究アプリケーションのサポート.
  • 結論:

    • 哺乳類遺伝子収集 (MGC) プロジェクトは,科学コミュニティにとって重要なリソースを成功裏に作成しました.
    • これらの全長cDNA資源の公開は,哺乳類遺伝学と分子生物学の研究を加速します.
    • このプロジェクトは,ゲノミクスにおける協調的で大規模な取り組みの重要性を強調しています.