Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Constitutive and Regulated Gene Expression01:27

Constitutive and Regulated Gene Expression

Gene expression in prokaryotes is governed by constitutive and regulated systems, allowing cells to balance the production of essential proteins with adaptive responses to environmental changes.Constitutive Gene ExpressionConstitutive, or housekeeping, genes are continuously expressed as they encode proteins vital for fundamental cellular processes. These include enzymes for glycolysis, ribosomal components for protein synthesis, and proteins involved in DNA replication. Their constant...

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

The expression of a nopaline synthase - human growth hormone chimaeric gene in transformed tobacco and sunflower callus tissue.

Plant molecular biology·2013
Same author

A set of novel Ti plasmid-derived vectors for the production of transgenic plants.

Plant molecular biology·2013
Same author

Genetic analysis of T-DNA insertions into the tobacco genome.

Plant cell reports·2013
Same author

Polyploidy and transposons.

Trends in ecology & evolution·2011
Same author

Cloning problems don't surprise plant biologists.

Science (New York, N.Y.)·2007
Same author

Host defenses to transposable elements and the evolution of genomic imprinting.

Cytogenetic and genome research·2005
Same journal

Erratum for the Research Article "Detecting supramolecular organic nanoparticles during heat wave".

Science (New York, N.Y.)·2026
Same journal

Local signals, systemic decline.

Science (New York, N.Y.)·2026
Same journal

The mechanics of liver regeneration.

Science (New York, N.Y.)·2026
Same journal

Computing in a memory with physics.

Science (New York, N.Y.)·2026
Same journal

Retraction.

Science (New York, N.Y.)·2026
Same journal

Making time.

Science (New York, N.Y.)·2026
関連記事をすべて見る

関連する実験動画

Updated: Jul 7, 2026

Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans
09:23

Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans

Published on: August 16, 2017

エピジェネティクス:抑圧による規制

A P Wolffe1, M A Matzke

  • 1Laboratory of Molecular Embryology, National Institute of Child Heath and Human Development, NIH, Building 18T, Room 106, Bethesda, MD 20892-5431, USA. awlme@helix.nih.gov

Science (New York, N.Y.)
|October 16, 1999
PubMed
まとめ
この要約は機械生成です。

エピジェネティクスは,DNA配列を変更することなく遺伝性遺伝子発現の変化を伴う. これらの重要なメカニズムは,発達,病気,遺伝子操作に影響を与え,その広範な関連性を強調しています.

さらに関連する動画

Using Caenorhabditis elegans for Studying Trans- and Multi-Generational Effects of Toxicants
08:58

Using Caenorhabditis elegans for Studying Trans- and Multi-Generational Effects of Toxicants

Published on: July 29, 2019

Genetic Screen for Identification of Multicopy Suppressors in Schizosaccharomyces pombe
13:22

Genetic Screen for Identification of Multicopy Suppressors in Schizosaccharomyces pombe

Published on: September 13, 2022

関連する実験動画

Last Updated: Jul 7, 2026

Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans
09:23

Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans

Published on: August 16, 2017

Using Caenorhabditis elegans for Studying Trans- and Multi-Generational Effects of Toxicants
08:58

Using Caenorhabditis elegans for Studying Trans- and Multi-Generational Effects of Toxicants

Published on: July 29, 2019

Genetic Screen for Identification of Multicopy Suppressors in Schizosaccharomyces pombe
13:22

Genetic Screen for Identification of Multicopy Suppressors in Schizosaccharomyces pombe

Published on: September 13, 2022

科学分野:

  • 遺伝学と分子生物学について
  • 発達生物学 発達生物学とは
  • 医療科学 医療科学とは

背景:

  • エピジェネティクスは,DNA配列の変化なしに遺伝性遺伝子発現の変化を研究する.
  • インプリントとパラミューテーションのような表遺伝子現象は,メンデルの遺伝に挑戦しています.
  • これらのメカニズムは正常な発達に不可欠ですが,がんなどの疾患に絡んでいます.

研究 の 目的:

  • 核酸配列ホモロジーが表遺伝子調節における役割を調査する.
  • エピジェネティックメカニズムがDNAメチル化,クロマチンの改造,RNAの周回にどのように影響するかを理解する.
  • 開発,病気,遺伝子操作における表遺伝子制御の影響を検証する.

主な方法:

  • 核酸配列認識とエピジェネティックターゲティングの関連性を調査する.
  • エピジェネティックメカニズムが細胞プロセスに与える影響を分析する.
  • 発達と疾患の病理学におけるエピジェネティックの役割を検討する.

主要な成果:

  • 核酸配列のホモロジーの認識は,表遺伝的変化と関連しています.
  • エピジェネティックメカニズムは,細胞を寄生性要素から保護しますが,遺伝的操作を妨げることができます.
  • エピジェネティック・コントロールの調節不全は,がんやその他のヒト疾患で観察されています.

結論:

  • エピジェネティックプロセスは,遺伝子発現の調節と発達に不可欠です.
  • エピジェネティクスを理解することは,医学とバイオテクノロジーの進歩にとって極めて重要です.
  • エピジェネティック不調は,ヒト疾患の病原性における重要な要因である.