ベータ・デフェンシン:デンドリット細胞とT細胞のCCR6を通して,先天的免疫と適応的免疫を結びつける
D Yang1, O Chertov, S N Bykovskaia
1Laboratory of Molecular Immunoregulation, Division of Basic Sciences, Intramural Research Support Program, SAIC Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA.
Science (New York, N.Y.)
|October 16, 1999
まとめ
ヒューマンベータ・デフェンシン (hBDs) は,微生物と戦うだけでなく,免疫細胞を惹きつけます. これらの防衛素は,CCR6受容体と相互作用することで未熟なデンドリット細胞とメモリT細胞を募集し,宿主の防御を支援します.
科学分野:
- 免疫学 免疫学とは
- 微生物学 微生物学とは
- 細胞生物学 細胞生物学
背景:
- 防衛素は,先天的な免疫システムの重要な構成要素であり,主にその抗微生物活性で知られています.
- 適応免疫を調節する彼らの役割は,あまり理解されていない.
研究 の 目的:
- 抗菌機能を超えたヒトβ-防衛素 (hBDs) の潜在的な役割を調査する.
- hBDが免疫細胞に化学的作用を持つかどうかを判断する.
主な方法:
- ケモカイン受容体 CCR6.6 を発現させるための細胞変異を利用した.
- CCR6-トランスフェクトされた細胞にhBDを用いたケモタキシスアッセイを行った.
- pertussis toxin と anti-CCR6 抗体を用いて hBD 誘発の化学反応のメカニズムを調査した.
- CCR6リガンド LARCとの競争性結合分析を実施しました.
主要な成果:
- 人間のβ-デフェンシンには,CCR6.6を発現する細胞に対する選択的化学作用が示された.
- この化学反応は百日咳毒素に敏感であり,Gタンパク質結合受容体の関与を示した.
- CCR6に対する抗体は,hBD誘発の細胞移動を阻害した.
- hBDsは,LARCのCCR6.への結合を競争力的に置き換えた.
結論:
- 人間のβ-デフェンシンは,CCR6経由で未成熟のデンドリット細胞とメモリT細胞の化学吸引剤として作用する.
- hBDは,重要な免疫細胞を感染部位に勧誘することによって,先天的および適応的免疫を橋渡しすることができます.
- CCR6とのこの相互作用は,適応性免疫反応を起こすための新しいメカニズムを示唆しています.
関連する概念動画
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