関連する実験動画
Updated: Jul 25, 2026

06:22
Neonatal Pial Surface Electroporation
Published on: May 7, 2014
カッチシグナル伝達によって媒介される皮質ニューライトの成長の接触依存抑制
N Sestan1, S Artavanis-Tsakonas, P Rakic
1Section of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA.
まとめ
ノッチ・シグナリングは,発達中の皮質ニューロンにおけるニューライトの成長を制御する. ニューロンの接触によって誘発されるNotchの活動の増加は,ニューロンの拡張を停止し,ニューロンの成熟を促進します.
科学分野:
- 神経科学は神経科学である.
- 細胞生物学 細胞生物学
- 発達生物学 発達生物学について
背景:
- 神経細胞の成長は,神経細胞の発達と回路形成に不可欠です.
- ニューロンの成熟には,ニューロンの成長能力の低下が伴う.
- この移行を調節する分子機構は完全に理解されていません.
研究 の 目的:
- 神経細胞の増殖と神経細胞の成熟の調節における接触媒介のNotchシグナル伝達の役割を調査する.
- Notchの活動が,皮質ニューロンのニューライトの拡張と収縮にどのように影響するかを決定する.
主な方法:
- マウスの脳皮質ニューロンのインビトロ培養.
- Notchのシグナル伝達活動の操作 (アップレギュレーションと阻害).
- ニューロンの伸縮,収縮,および神経間接触の観察と定量化.
主要な成果:
- Notchの活動の増加は,神経細胞間の接触の増加と神経細胞の成長停止と相関する.
- 高度なNotchシグナリングは,神経細胞の拡張を阻害したり,発達中の神経細胞の収縮を誘導したりします.
- Notchシグナル伝達の阻害は,Notch活性が高い成熟ニューロンにおけるニューライト拡張を促した.
結論:
- 接触媒介のNotchシグナリングは,神経細胞の成長の重要なレギュレータとして作用します.
- ニューロンの接触時にノッチ受容体の活性化は,成長を制限し,ニューロンの成熟を促進します.
- ノッチ・シグナリングは,シナプス形成とニューライト拡張の停止の間の分子リンクを提供します.
関連する概念動画
Contact-dependent Signaling
Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
Gap Junctions
In animal cells, gap junctions are formed...
Gap Junctions
In animal cells, gap junctions are formed...
Synaptic Signaling
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Synaptic Signaling
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
Overview of Cell Signaling
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Immunoglobulin-like Cell Adhesion Molecules
Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Neuronal Communication
Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...

