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Updated: Jul 20, 2026

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
06:54

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

SnoNオンコタンパク質によるTGFβシグナル伝達のネガティブなフィードバックの調節

S L Stroschein1, W Wang, S Zhou

  • 1Life Sciences Division, Lawrence Berkeley National Laboratory, and Department of Molecular and Cell Biology, University of California, Berkeley, 229 Stanley Hall, Mail Code 3206, Berkeley, CA 94720, USA.

Science (New York, N.Y.)
|October 26, 1999
PubMed
まとめ

SnoNオンコタンパク質は,Smadタンパク質と相互作用することによって,変形成長因子β (TGFβ) 信号伝達を抑制する. TGF-β刺激は,最初はSnoNを劣化させ,遺伝子の活性化を可能にしますが,後にSnoNを増加させ,信号伝達を終了させます.

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