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Updated: May 1, 2026

RNAi Screening to Identify Postembryonic Phenotypes in C. elegans
09:40

RNAi Screening to Identify Postembryonic Phenotypes in C. elegans

Published on: February 13, 2012

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C. elegans の rde-1 遺伝子,RNA 干渉,およびトランポゾンサイレンシング

H Tabara1, M Sarkissian, W G Kelly

  • 1Department of Cell Biology, Program in Molecular Medicine, University of Massachusetts Cancer Center, Worcester 01605, USA.

Cell
|October 27, 1999
PubMed
まとめ

研究者らは,二重鎖RNA干渉 (RNAi) に抵抗するC. elegans変異体を特定した. この研究は,トランポゾン静止におけるRNAiの潜在的な役割を明らかにし,遺伝子調節機構の洞察を提供している.

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RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
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