関連する実験動画
Updated: Jul 24, 2026
13:21
Determining heat and mechanical pain threshold in inflamed skin of human subjects
Published on: January 14, 2009
病理的な痛みの皮質起源は,皮質にある
1Department of Physiology, University of Otago Medical School, Dunedin, New Zealand. john.harris@stonebow.otago.ac.nz
Lancet (London, England)
|October 30, 1999
まとめ
幻肢の痛みや重複性ストレスの損傷は,脳から発生する可能性があります.
科学分野:
- 神経科学は神経科学である.
- 痛みに関する研究 痛みに関する研究
- エンジンの制御装置
背景:
- 幻肢の痛みのように,明らかな組織損傷のない痛みは,長い間医学的なパズルです.
- 最近の発見は,感覚信号と運動信号の不一致に関連した脳の活動を強調しています.
- 繰り返しのストレスの傷害や焦点手ディストニアのような状態は,脳の感覚運動皮質の変化を伴う.
研究 の 目的:
- 直接的な組織損傷がない場合に痛みの知覚の基礎となる神経機構を探求する.
- 病理的な痛みにおけるセンソモーター皮質とプロピオセプティブ表現の役割を調査する.
- 異なる種類の痛みと感覚不一致状態の間の並列を描画する.
主な方法:
- 皮質活動に関する最近の神経科学の発見のレビュー.
- 感覚運動皮質の可塑性と痛みを伴う状態の分析.
- 痛みのメカニズムと,運動病のような感覚的衝突現象の比較.
主要な成果:
- 特定の皮質領域は,運動意図,運動意識,視覚フィードバックの不一致によって活性化されます.
- 感覚運動皮質のプラスチックの変化は,幻肢の感覚と重複的なストレスの損傷と関連しています.
- 無秩序なプロプロイセプティブ皮質表現は,誤った運動感覚の不一致をシグナルすることによって,病理的な痛みを引き起こす可能性があります.
結論:
- 幻肢の痛みや重複的なストレスの傷害を含む病理的な痛みは,感覚情報の無秩序な皮質の処理から生じる可能性があります.
- 感覚フィードバックの不一致,特に感覚運動系内の不一致は,痛みを発生させる重要な要因です.
- これらの脳メカニズムの理解は,明確な組織病理学なしに痛みを治療するための新しい道を開くことができます.
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