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Updated: Jul 25, 2026

11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
まとめ
牛皮病の治療薬であるメソトレクサートは,がんのリスクについて研究されました. この研究は,患者における全体的ながん発生率の増加は認められなかったが,肝疾患の死亡率は高かった.
科学分野:
- 皮膚科 皮膚科について
- 腫瘍学 腫瘍学
- 薬理学 薬理学とは
背景:
- メソトレクサートは,ソーリアシスの一般的な治療法です.
- メトトレキサートの潜在的発がん性作用に関する懸念も存在します.
- 長期的な安全性データは,広く使用されているこの薬剤にとって極めて重要です.
研究 の 目的:
- メトトレキサートで治療された患者における悪性腫瘍の長期的な発生率を調査する.
- 牛皮病に対するメトトレキサート療法に関連する全死亡率と特定の癌リスクの評価.
主な方法:
- 224人の患者からなるコホートは,1960年から1965年の間にメトトレキサート治療を開始した.
- 205人の患者に悪性腫瘍の発生率と死亡率に関するフォローアップデータを収集した.
- 統計分析を行い,観測された比率と予想された比率を比較した.
主要な成果:
- 内部悪性腫瘍の全体的な発生率の統計的に有意な増加は観察されなかった.
- 既往の肝疾患を有する患者の死亡率はより高いことが判明しました.
- 観察された症例の中で,単一のタイプの腫瘍が優位ではなかった.
結論:
- 牛皮病に対するメソトレキサート治療は,内部悪性腫瘍の全体的なリスクを増加させるようには見えません.
- 医者は,メトトレキサート治療を受けている患者の肝疾患に警戒すべきです.
- 特定の危険因子と長期的な結果を調査するために,さらなる研究が必要になるかもしれません.
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