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Updated: Jul 8, 2026

Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells
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転写因子ドッキングを通じてPPARgammaコアクティベーター-1の活性化

P Puigserver1, G Adelmant, Z Wu

  • 1Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

Science (New York, N.Y.)
|November 13, 1999
PubMed
まとめ

ペロキシソーム増殖器活性化受容体ガンマ共活性化剤-1 (PGC-1) は,遺伝子転写を活性化するために転写因子結合を必要とします. PPARgammaへのドッキングにより,PGC-1はSRC-1およびCBP/p300のコアクティベーターを募集し,転写活動を強化することができます.

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