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The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
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慢性ノシセプションの伝播は,物質P受容体を発現する脊髄神経によって行われます

M L Nichols1, B J Allen, S D Rogers

  • 1Department of Preventive Sciences, University of Minnesota, Minneapolis, MN 55455, USA.

Science (New York, N.Y.)
|November 24, 1999
PubMed
まとめ

脊髄の物質P受容体 (SPR) を発現するニューロンをターゲットにすることで,慢性的な痛みを軽減します. これらのニューロンを切除すると,神経疾患および炎症性疼痛が軽減され,SPRニューロンが慢性疼痛状態における重要な役割を果たすことを示唆しています.

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