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Updated: Jul 6, 2026

Targeting Cysteine Thiols for in Vitro Site-specific Glycosylation of Recombinant Proteins
11:25

Targeting Cysteine Thiols for in Vitro Site-specific Glycosylation of Recombinant Proteins

Published on: October 4, 2017

cGMP依存タンパク質キナーゼIalphaとの特定の相互作用により,ミオシンフォスファタゼの調節

H K Surks1, N Mochizuki, Y Kasai

  • 1Molecular Cardiology Research Institute and Cardiology Division, Department of Medicine, Tufts University School of Medicine and New England Medical Center, Boston, MA 02111, USA.

Science (New York, N.Y.)
|November 24, 1999
PubMed
まとめ

サイクルグアナシンモノフォスファート依存タンパク質キナーゼイアルファ (cGKIalpha) は,ミオシン結合サブユニット (MBS) 相互作用を通じて,滑らかな筋肉の収縮器官を標的にします. この相互作用は,ミオシン・ライトチェーン・デフォスフォリレーションを制御することによって,血管の滑らかな筋肉トーンを調節するために重要である.

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GTPases and their Regulation

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Heterotrimeric G proteins are guanine nucleotide-binding proteins. As the name suggests, heterotrimeric G proteins are composed of three subunits: alpha, beta, and gamma. They remain GDP-bound or GTP-bound inside the cells and switch between inactive/active states. The Gα subunit possesses the nucleotide-binding pocket that binds guanine nucleotides and switches between GDP or GTP-bound states. In contrast, the Gꞵ and Gγ subunits are always bound together with high affinity and are together...
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GPCRs Regulate Adenylyl Cylase Activity

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